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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Methylglyoxal, cognitive function and cerebral atrophy in older people
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Methylglyoxal, cognitive function and cerebral atrophy in older people

机译：老年人甲基乙二醛，认知功能和脑萎缩

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Background.The effects of advanced glycation endproducts on cognition and brain structure are poorly understood. We studied associations of the advanced glycation endproduct precursor methylglyoxal (MGO) with cognitive function and brain volumes in older people.Methods.Nondemented participants in the Tasmanian Study of Cognition and Gait underwent cognitive testing and brain magnetic resonance imaging scans. Brain volumes were obtained by magnetic resonance imaging scan segmentation and statistical parametric mapping procedures. Serum MGO was measured after derivatization to methylquinoxaline by high pressure liquid chromatography and UV detection. Linear regression was used to examine associations of log-transformed MGO with cognitive scores and brain volumes adjusting for potential confounding by age, sex, education, mood, insulin resistance, history of stroke, vascular risk factors, alcohol intake, and psychoactive medication use.Results.There were 378 participants, mean age 72.1 years (SD 7.1), 55% male. Greater MGO was associated with poorer memory (?? =-.12, 95% confidence interval:-0.22,-0.02, p =. 02) and executive function, the latter being greater among those with a history of stroke (MGO ?? stroke ?? =. 48, 95% confidence interval: 0.17, 0.79, p =. 002). Greater MGO was associated with lower grey matter volume (?? =-6.42, 95% confidence interval-11.82,-1.11, p =. 02) but not with white matter volume, white matter lesion volume, or hippocampal volume.Conclusions.These results support the investigation of the role of the advanced glycation endproduct precursor methylglyoxal in cognitive decline and neurodegeneration in older people. ? 2012 The Author.
机译：背景：人们对高级糖基化终产物对认知和大脑结构的影响知之甚少。我们研究了晚期糖基化终产物前体甲基乙二醛（MGO）与老年人的认知功能和脑容量的关联。方法。塔斯马尼亚认知与步态研究的参与者参加了认知测试和脑磁共振成像扫描。通过磁共振成像扫描分割和统计参数映射程序获得脑容量。高压液相色谱法和紫外检测法衍生化成甲基喹喔啉后，测定血清MGO。使用线性回归检查对数转换的MGO与认知评分和脑容量的关联，以调整年龄，性别，教育程度，情绪，胰岛素抵抗，中风病史，血管危险因素，饮酒和精神药物的潜在混杂因素。结果：共有378名参与者，平均年龄72.1岁（SD 7.1），男性占55％。 MGO越高与记忆力越差（Δε=-。12，95％置信区间：-0.22，-0.02，p = .02）和执行功能有关，后者在有中风病史的患者中就更强（MGO？冲程Δθ＝ .48，95％置信区间：0.17，0.79，p ＝ .002）。较高的MGO与较低的灰质体积相关（Δε= -6.42，95％置信区间为11.82，-1.11，p = .02），但与白质体积，白质病变体积或海马体积无关。研究结果支持了晚期糖基化终产物前体甲基乙二醛在老年人认知能力下降和神经变性中的作用的研究。 ？ 2012作者。

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