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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Caloric restriction, metabolic rate, and entropy.
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Caloric restriction, metabolic rate, and entropy.

机译：热量限制，代谢率和熵。

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Caloric restriction increases life span in many types of animals. This article proposes a mechanism for this effect based on the hypothesis that metabolic stability, the capacity of an organism to maintain steady state values of redox couples, is a prime determinant of longevity. We integrate the stability-longevity hypothesis with a molecular model of metabolic activity (quantum metabolism), and an entropic theory of evolutionary change (directionality theory), to propose a proximate mechanism and an evolutionary rationale for aging. The mechanistic features of the new theory of aging are invoked to predict that caloric restriction extends life span by increasing metabolic stability. The evolutionary model is exploited to predict that the large increases in life span under caloric restriction observed in rats, a species with early sexual maturity, narrow reproductive span and large litter size, and hence low entropy, will not hold for primates. We affirm that in the case of humans, a species with latesexual maturity, broad reproductive span and small litter size, and hence high entropy, the response of life span to caloric restriction will be negligible.
机译：热量限制会延长许多动物的寿命。本文基于以下假设提出了一种影响这种作用的机制：代谢稳定性（生物体维持氧化还原对稳态值的能力）是长寿的主要决定因素。我们将稳定性-寿命假设与代谢活动的分子模型（量子代谢）和进化变化的熵理论（方向性理论）相结合，提出了衰老的近似机理和进化原理。引用新的衰老理论的机理特征来预测热量的限制会通过增加代谢稳定性来延长寿命。利用进化模型来预测在大鼠的热量限制下寿命的大幅度增加，这种物种具有早性成熟，狭窄的繁殖跨度和较大的窝产仔数，因此熵低，对于灵长类动物将不成立。我们确认，对于人类来说，具有晚熟性，繁殖范围广，窝产仔数小，因此具有很高的熵的物种，寿命对热量限制的响应可以忽略不计。

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