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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span
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A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span

机译：一种测量整个成年寿命中循环生物标志物与身体表现之间关联的新型分析技术

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Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability. We hypothesized that high concentrations of circulating biomarkers would be associated with lower functioning across study populations representing the adult life span. The data were from four intervention and two observational studies with ages ranging 22-89 years. Biomarkers assayed included inflammatory, coagulation, and endothelial function markers. Physical performance was measured either by VO2 peak (studies of young and middle-aged adults) or usual gait speed (studies of older adults). Partialled (by age, body mass index, race, and sex) and weighted common correlations were calculated between biomarkers and physical performance. Homogeneity of the associations was also assessed. Interleukin-6 (weighted r = -.22), tumor necrosis factor receptor 2 (weighted r = -.19), D-dimer (weighted r = -.16), tumor necrosis factor receptor 1 (weighted r = -.15), granulocyte colony-stimulating factor (weighted r = -.14), and tumor necrosis factor alpha (weighted r = -.10) were all significantly inversely correlated with physical performance (p<.05). All significant correlations were homogeneous across studies. In summary, we observed consistent inverse associations between six circulating biomarkers and objective measures of physical performance. These results suggest that these serum biomarkers may be broadly applicable for detection, trajectory, and treatment monitoring of physical function across the life span or possibly for midlife predictors of functionally deleterious conditions.
机译：了解成年人整个生命周期中循环生物标志物与身体机能之间的关联可以帮助更好地描述导致残疾的机械途径。我们假设循环生物标志物的高浓度与代表成年人寿命的研究人群的功能降低有关。数据来自四项干预和两项观察性研究，年龄在22-89岁之间。分析的生物标志物包括炎症，凝血和内皮功能标志物。通过VO2峰值（青年和中年成年人的研究）或通常的步态速度（老年人的研究）来衡量身体机能。计算了生物标志物与身体机能之间的部分差异（按年龄，体重指数，种族和性别）和加权的常见相关性。协会的同质性也进行了评估。白介素6（加权r = -.22），肿瘤坏死因子受体2（加权r = -.19），D-二聚体（加权r = -.16），肿瘤坏死因子受体1（加权r = -.15） ），粒细胞集落刺激因子（权重r = -.14）和肿瘤坏死因子α（权重r = -.10）均与身体表现显着负相关（p <.05）。在所有研究中，所有显着的相关性都是同质的。总而言之，我们观察到六个循环生物标志物与身体机能的客观测量之间一致的负关联。这些结果表明，这些血清生物标志物可能广泛适用于整个生命周期中身体功能的检测，轨迹和治疗监测，或者可能适用于功能有害状况的中年预测指标。

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