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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A randomized, crossover trial of high-carbohydrate foods in nursing home residents with Alzheimer's disease: associations among intervention response, body mass index, and behavioral and cognitive function.
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A randomized, crossover trial of high-carbohydrate foods in nursing home residents with Alzheimer's disease: associations among intervention response, body mass index, and behavioral and cognitive function.

机译：高碳水化合物食品在阿尔茨海默氏病疗养院居民中的一项随机，交叉试验：干预反应，体重指数以及行为和认知功能之间的关联。

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BACKGROUND: Despite recognition that weight loss is a problem in elderly persons with probable Alzheimer's disease (AD), increasing their food intake remains a challenge. To effectively enhance intake, interventions must work with individuals' changing needs and intake patterns. Previously, the authors reported greater food consumption at breakfast, a high-carbohydrate meal, compared with dinner, and shifts toward carbohydrate preference at dinner in those with increased behavioral difficulties, low body mass index, or both. METHODS: Thirty-four nursing home residents with probable AD who ate independently participated in a randomized, crossover, nonblinded study of two nutrition interventions. The intervention described here included replacing 12 nonconsecutive "traditional" dinners with meals high in carbohydrate but comparable to traditional dinners in protein. Measures included weighed food intake, body weight, cognitive function (as assessed using the Severe Impairment Battery and Global Deterioration Scale), behavioral disturbances (as assessed using the Neuropsychiatric Inventory-Nursing Home Version), and behavioral function (as assessed using the London Psychogeriatric Rating Scale). RESULTS: Group mean dinner and 24-hour energy intake increased during the intervention phase compared with baseline, protein intake was unaffected, and carbohydrate intake increased. Increased dinner intake, attributable to intervention foods, was achieved in 20 of 32 of participants who completed the study and was associated with increased carbohydrate preference, poorer memory, and increased aberrant motor behavior. Those with low body mass indices were the most resistant to the intervention. CONCLUSIONS: Providing a high-carbohydrate meal for dinner increases food intake in seniors at later stages of the disease who are experiencing cognitive and behavioral difficulties, possibly as a result of a shift in preference for high-carbohydrate foods.
机译：背景：尽管人们认识到减肥是可能患有阿尔茨海默氏病（AD）的老年人的问题，但增加食物摄入量仍然是一个挑战。为了有效地提高摄入量，干预措施必须适应个人不断变化的需求和摄入方式。以前，作者报告说，与晚餐相比，早餐，高碳水化合物餐时的食物消耗更多，并且在行为障碍增加，体重指数低或两者兼而有之的人中，晚餐时转向碳水化合物偏爱。方法：34位有可能患有AD的疗养院居民独立进餐，参加了两项营养干预措施的随机，交叉，非盲研究。这里描述的干预措施包括用高碳水化合物但与蛋白质传统晚餐相当的膳食代替12种非连续的“传统”晚餐。措施包括称量食物摄入量，体重，认知功能（使用严重损伤量表和整体恶化量表评估），行为障碍（使用神经精神病学库存-疗养院版评估）和行为功能（使用伦敦精神病学评估）评分量表）。结果：与基线相比，干预阶段的组平均晚餐和24小时能量摄入增加，蛋白质摄入未受影响，碳水化合物摄入增加。在完成研究的32位参与者中，有20位参与者的晚餐食物摄入量增加（归因于干预食品），这与碳水化合物偏好增加，记忆力下降和异常运动行为增加有关。体重指数低的人最不愿意干预。结论：在晚餐时提供高碳水化合物餐会增加患有认知和行为困难的疾病晚期患者的食物摄入，这可能是由于偏爱高碳水化合物食品的结果。

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