...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Knee >Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid.
【24h】

Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid.

机译：高分子量透明质酸治疗膝关节骨性关节炎患者后疼痛强度变化与滑液三磷酸腺苷水平的相关性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We sought to determine whether a clinical association exists between osteoarthritis (OA)-associated knee pain and adenosine triphosphate (ATP) levels in synovial fluid (SF). A total of 28 patients with 28 primary OA knees were included. They routinely received intra-articular injection of high-molecular-weight hyaluronic acid (HA) once weekly for 5 weeks (treated group). Eight patients without knee pain who had undergone an operation for anterior or posterior cruciate ligament reconstruction 2 years ago were also examined (control group). SF and blood ATP concentrations, total amount of ATP, total SF volume, and Visual Analogue Scale (VAS) scores in all patients were measured and we compared pre-treatment values with those 1 week after the final treatment. We evaluated the correlation of change in total ATP (DeltaATP) and change in VAS score (DeltaVAS), DeltaVAS and change in SF volume (DeltaSF), and ATP concentration in SF and blood. In the treated group, SF ATP concentration, total amount of ATP, SF volume, and VAS score were all significantly lower post-treatment than pre-treatment (p = 0.0005, 0.0003, 0.0022, and < 0.0001, respectively). In treated group, DeltaVAS was significantly associated with DeltaATP (r = 0.56, p = 0.0032), DeltaSF was significantly associated with DeltaVAS (r = 0.78, p < 0.0001), and total amount of SF ATP and SF volume at pre-treatment were significantly higher than the control group (p < 0.0001, p < 0.0001) We demonstrated an association between SF ATP level changes and OA knee pain, which should facilitate a further understanding of OA pain mechanisms.
机译：我们试图确定骨关节炎（OA）相关的膝关节疼痛与滑液（SF）中三磷酸腺苷（ATP）水平之间是否存在临床关联。包括28例原发性OA膝关节28例。他们常规每周一次接受高分子量透明质酸（HA）的关节内注射，持续5周（治疗组）。还检查了2年前接受过前交叉韧带或后交叉韧带重建手术的8例无膝关节疼痛的患者（对照组）。测量所有患者的SF和血液ATP浓度，ATP总量，总SF量以及视觉模拟量表（VAS）得分，然后将治疗前的值与最终治疗后1周的值进行比较。我们评估了总ATP（DeltaATP）变化与VAS评分（DeltaVAS），DeltaVAS与SF体积变化（DeltaSF）以及SF和血液中ATP浓度变化之间的相关性。在治疗组中，治疗后的SF ATP浓度，ATP总量，SF量和VAS评分均显着低于治疗前（分别为p = 0.0005、0.0003、0.0022和<0.0001）。在治疗组中，DeltaVAS与DeltaATP显着相关（r = 0.56，p = 0.0032），DeltaSF与DeltaVAS显着相关（r = 0.78，p <0.0001），并且治疗前的SF ATP总量和SF体积为显着高于对照组（p <0.0001，p <0.0001）我们证明了SF ATP水平变化与OA膝关节疼痛之间的关联，这应该有助于进一步了解OA疼痛机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号