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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Causes of permanent childhood hearing impairment.
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Causes of permanent childhood hearing impairment.

机译：儿童永久性听力障碍的原因。

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INTRODUCTION: The causes of Permanent Childhood Hearing Impairment (PCHI) are often quoted as being hereditary in 50%, acquired in 25%, and unknown in 25% of cases. Interest in the causes of PCHI has grown recently due to increasing diagnostic possibilities. We investigated the evidence for the reported distribution of these causes. METHODS: Population-based study and a systematic review. Inclusion criteria for population-based study: children born between 2003 and 2005, resident in The Netherlands at birth, known at an Audiology Center with PCHI at the age of 3-5 years. The causes of PCHI were determined prospectively by detection of congenital cytomegalovirus on dried blood spots and/or genetic diagnostic investigations in addition to reviewing data from medical records. A systematic review was carried out using three terms (hearing loss, infant, and etiology) and limited to articles published between January 1997 and July 2009. Main outcome measures were: the (weighted) proportions of the various causes of PCHI following diagnostic investigations. RESULTS: In the study-population (n = 185) a hereditary cause was found in 38.9%, acquired cause in 29.7%, miscellaneous cause in 7.1%, and the cause remained unknown in 24.3%. The systematic review of the literature (n = 9 articles) resulted in a weighted mean of 30.4% hereditary, 19.2% acquired, and 48.3% unknown causes of PCHI. DISCUSSION: The systematic review and the results of the population-based study provided little support for the generally accepted distribution of causes of PCHI.
机译：引言：永久性儿童听力障碍（PCHI）的病因通常是遗传性的，占50％，获得性占25％，未知的占25％。最近，由于诊断可能性的增加，人们对PCHI病因的兴趣也越来越高。我们调查了这些原因的报告分布的证据。方法：基于人群的研究和系统的回顾。基于人群的研究的纳入标准：2003年至2005年之间出生的儿童，出生时居住在荷兰，在3-5岁的PCHI听觉中心就诊。通过检查干血斑上的先天性巨细胞病毒和/或除了检查病历中的数据外，还通过基因诊断研究前瞻性地确定了PCHI的病因。系统评价使用了三个术语（听力损失，婴儿和病因）进行，并且仅限于1997年1月至2009年7月之间发表的文章。主要结局指标是：诊断调查后各种PCHI病因的（加权）比例。结果：在研究人群（n = 185）中，遗传原因占38.9％，后天原因占29.7％，其他原因占7.1％，未知原因在24.3％。对文献的系统评价（n = 9篇文章）导致遗传性PCHI的加权平均值为30.4％，获得性的加权平均值为19.2％，未知原因的加权平均值为48.3％。讨论：系统评价和基于人群的研究结果几乎没有为普遍接受的PCHI病因分布提供支持。

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