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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Glottographic measures before and after levodopa treatment in Parkinson's disease.
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Glottographic measures before and after levodopa treatment in Parkinson's disease.

机译：左旋多巴治疗帕金森氏病之前和之后的肾盂造影测量。

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OBJECTIVES: Investigate the usefulness of acoustic and glottographic measures for detecting effects of levodopa (L-dopa) treatment on vocal function of individuals with idiopathic Parkinson's disease. STUDY DESIGN: Compare recordings of vowels sustained at a target comfortable loudness level obtained before and after L-dopa treatment from 15 individuals with idiopathic Parkinson's disease showing signs of tremor. METHODS: A simultaneous acoustic, airflow, and electroglottographic recording technique was employed to record vowels phonated by subjects before and after L-dopa treatment. Algorithms were developed to derive from the recorded signal measures of fundamental frequency, SPL airflow rate, speed quotient (ratio of glottal opening to closing time time), and short- and long-term phonatory instability. A series of paired Student t tests or signed rank tests were performed to compare the pretreatment and posttreatment groups on these measures. RESULTS: Measures of speed quotient, acoustic shimmer (cycle-to-cycle amplitude perturbation), and the extent of tremor derived from acoustic intensity contours were found to significantly decrease after medication. Sound pressure level tended to increase after medication. The acoustic jitter (cycle-to-cycle frequency perturbation) and the extent of tremor derived from airflow signals did not significantly differentiate between premedication and postmedication voices. CONCLUSIONS: Objective measures of acoustic and electroglottographic signals are useful in monitoring the pharmacologic response of Parkinson's disease, reflecting decrease of laryngeal rigidity and short- and long-term acoustic amplitude fluctuation after L-dopa treatment.
机译：目的：研究声学和声像图测量方法对左旋多巴（L-多巴）治疗对特发性帕金森氏病患者声音功能的影响的检测作用。研究设计：比较从15名患有震颤迹象的特发性帕金森氏病患者接受左旋多巴之前和之后获得的目标舒适响度水平下的元音记录。方法：采用同时的声学，气流和电描记法记录技术，以记录左旋多巴治疗前后受试者发声的元音。开发了算法以从记录的信号测量中得出基本频率，SPL气流速率，速度商（声门打开与关闭时间的比率）以及短期和长期的发声不稳定性。进行了一系列成对的Student t检验或带符号秩检验，以比较预处理组和后处理组在这些度量上的差异。结果：发现服药后，速度商，声学闪光（周期间振幅扰动）和由声强等高线引起的震颤程度的测量值显着降低。用药后声压级有升高的趋势。声学抖动（周期间的频率扰动）和气流信号引起的震颤程度并未明显区别服药前和服药后的声音。结论：客观的声电图信号测量可用于监测帕金森氏病的药理反应，反映出L-多巴治疗后喉劲度降低以及短期和长期声振幅波动。

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