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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Swallow function in patients before and after intra-arterial chemoradiation.
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Swallow function in patients before and after intra-arterial chemoradiation.

机译：动脉内放化疗前后患者的吞咽功能。

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OBJECTIVES/HYPOTHESIS: To prospectively evaluate swallow function in patients with advanced head and neck cancer before and after completion of intra-arterial chemoradiation therapy and planned neck dissection. STUDY DESIGN: Prospective nonrandomized study.METHODS Swallow function was evaluated in 11 patients with resectable T4 and selected T3 head and neck cancer before and, on average, 19 weeks after completion of treatment. RESULTS: The Performance Status Scale demonstrated worse scores for both eating in public (P =.004) and normalcy of diet (P =.004) after treatment. Patients who underwent neck dissections had significantly worse scores (P =.02) in normalcy of diet. A significant decline was noted in swallowing functional measures at the time of the repeat evaluation (P =.02). Videofluoroscopic swallow studies revealed altered swallow function in 9 of 11 patients before treatment, with aspiration seen in 3 patients. Following treatment, the incidence of aspiration increased to seven patients. Tongue base retraction, reduced laryngeal elevation, and increased laryngeal vestibule penetration of thick liquid were all statistically significantly worse after treatment. The overall score on the quality of life instrument was not significantly changed from before to after treatment. CONCLUSIONS: The majority of patients demonstrated significantly worse swallow function on all three methods of analysis at 19 weeks after completion of treatment. Continued detailed monitoring of patients' swallow function is critical in determining long-term effects of intra-arterial chemoradiation therapy and neck dissection.
机译：目的/假设：前瞻性评估晚期头颈癌患者在进行动脉内化学放疗和计划中的颈清扫术前后的吞咽功能。研究设计：一项前瞻性非随机研究。方法在治疗之前和平均完成治疗19周后，对11例可切除的T4和选择的T3头颈癌患者进行了吞咽功能评估。结果：表现状态量表显示在公共饮食（P = .004）和治疗后饮食正常（P = .004）方面得分均较差。进行颈清扫术的患者在饮食常规方面的得分明显较差（P = .02）。重复评估时，吞咽功能指标明显下降（P = .02）。电镜下吞咽研究显示，治疗前11例患者中有9例吞咽功能发生了改变，其中3例患者出现误吸。治疗后，误吸的发生率增加到七例。经统计学处理后，舌根回缩，喉部抬高降低和喉前庭穿透浓液增加均在统计学上显着恶化。生活质量仪器的总体评分从治疗前到治疗后均无明显变化。结论：大多数患者在完成治疗后19周时，所有三种分析方法均显示吞咽功能显着恶化。持续详细监测患者的吞咽功能对于确定动脉内化学放疗和颈部解剖的长期疗效至关重要。

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