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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Reduction of salivary flow with botulinum toxin: extended report on 33 patients with drooling, salivary fistulas, and sialadenitis.
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Reduction of salivary flow with botulinum toxin: extended report on 33 patients with drooling, salivary fistulas, and sialadenitis.

机译：肉毒杆菌毒素减少唾液流量：33例流口水，唾液瘘和ist骨腺炎患者的扩展报告。

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OBJECTIVES/HYPOTHESIS: The aim of the study was the evaluation of the clinical data of 33 patients who had had drooling attributable to various diseases, salivary fistulas, and sialadenitis and had been treated with injection of botulinum toxin type A (Botox). A controlled follow-up study documenting efficiency, possible side effects, and duration of the effect of treatment was also performed. STUDY DESIGN: Retrospective clinical evaluation. METHODS: Thirty-three patients with drooling attributable to head and neck carcinoma, neurodegenerative diseases, stroke, or idiopathic hypersalivation or with salivary fistula or chronic sialadenitis received injections of 20 to 65 U botulinum toxin type A into salivary glands under sonographic control. The entire salivary flow rate and the output per minute of the salivary analytes thiocyanate, total protein, alpha-amylase, acid phosphatase, kallikrein, and immunoglobulin A were measured at various times before and after injection. The patients were examined withregard to severity of their symptoms, including sonographic control investigation of their cephalic salivary glands. RESULTS: Twenty-six patients (79% of all patients) reported a distinct improvement of their symptoms after toxin injection. Seven patients noted a return of high salivation rates and requested a second injection after 4 to 7 months. Duration of toxin effect varied widely among individuals. In general, salivary flow rates and thiocyanate output dropped sharply within 1 week after injection and had increased again after a period of 12 to 16 weeks. Conversely, amylase outputs increased during this period, whereas the outputs of the other analytes remained roughly constant. Sonography did not reveal any major changes in salivary gland parenchyma, and side effects were not noted. CONCLUSION: Reduction of salivary flow in patients with drooling, salivary fistulas, or chronic sialadenitis by local injection of botulinum toxin type A into the salivary glands proved to be a dependable therapy for these disorders, as shown in the present extended report on 33 patients. Side effects were not observed. The effect of toxin application lasted for approximately 3 months. Based on their results, the authors recommend botulinum toxin injection as the therapy of choice in patients with the problem of drooling.
机译：目的/假设：本研究的目的是评估33例因各种疾病，唾液瘘和骨腺炎而流口水并接受A型肉毒杆菌毒素治疗的患者的临床数据。还进行了对照随访研究，记录了疗效，可能的副作用和治疗效果的持续时间。研究设计：回顾性临床评估。方法：对33例因头颈癌，神经退行性疾病，中风或特发性唾液分泌过多或唾液瘘或慢性涎腺炎引起的流口水的患者，在超声检查下向唾液腺注射20至65 U的A型肉毒杆菌毒素。在注射前后的不同时间测量唾液分析物硫氰酸盐，总蛋白，α-淀粉酶，酸性磷酸酶，激肽释放酶和免疫球蛋白A的总唾液流速和每分钟的输出量。检查患者的症状严重程度，包括对其头唾液腺进行超声检查。结果：26例患者（占所有患者的79％）在注射毒素后报告其症状明显改善。 7名患者注意到流涎率又恢复高，并在4至7个月后再次注射。毒素作用的持续时间在个体之间差异很大。通常，唾液流速和硫氰酸盐产量在注射后1周内急剧下降，并在12至16周后再次上升。相反，在此期间淀粉酶输出增加，而其他分析物的输出则大致保持恒定。超声检查未发现唾液腺实质有任何重大变化，也未发现副作用。结论：通过向唾液腺局部注射A型肉毒杆菌毒素，减少流口水，唾液瘘或慢性涎腺炎患者的唾液流量被证明是治疗这些疾病的可靠方法，如本扩展研究报告所显示的33例患者所示。没有观察到副作用。施加毒素的效果持续了大约3个月。基于他们的结果，作者建议肉毒杆菌毒素注射作为流口水患者的首选治疗方法。

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