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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Cranial bone regeneration using a composite scaffold of Beta-tricalcium phosphate, collagen, and autologous bone fragments.
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Cranial bone regeneration using a composite scaffold of Beta-tricalcium phosphate, collagen, and autologous bone fragments.

机译：使用β-磷酸三钙，胶原蛋白和自体骨碎片的复合支架进行颅骨再生。

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OBJECTIVE: The aim of our study was to examine the tissue response and new bone formation induced by beta-tricalcium phosphate (beta-TCP), collagen, and autologous bone fragments with fibrin glue implanted into a cranial bone defect. MATERIALS AND METHODS: Granulated beta-TCP and collagen from porcine skin were mixed and freeze-dried. The weight ratio of both materials was 98:2. The composite scaffold for bone regeneration was composed of this artificial material and autologous bone fragments. Five adult beagle dogs were used. A cranial bone defect (2 cmx2 cm) was created in each dog. The animals were divided into two groups. In group 1 (n=3), the cranial bone defect was closed by replacing the original free bone flap, and the residual fissure and burr holes were filled with the composite scaffold with fibrin glue. In group 2 (n=2), the bone defect was closed only by replacing the original free bone flap. Three months after the treatment, computed tomography and histologic examinations were done in allanimals. RESULTS: In all dogs in group 1, the defects were almost closed by new bone; whereas in group 2, the defects were filled with fibrous tissues instead of bone. CONCLUSION: This study showed that the composite scaffold made of beta-TCP, collagen, and autologous bone fragments with fibrin glue enabled reconstruction of cranial bone defects without the usual fixation materials.
机译：目的：我们的研究目的是用纤维蛋白胶植入颅骨缺损中，检查由β-磷酸三钙（β-TCP），胶原蛋白和自体骨碎片诱导的组织反应和新骨形成。材料与方法：将猪皮肤颗粒状的β-TCP和胶原蛋白混合并冷冻干燥。两种材料的重量比为98：2。用于骨再生的复合支架由这种人造材料和自体骨碎片组成。使用了五只成年比格犬。在每只狗中产生了颅骨缺损（2 cmx2 cm）。将动物分为两组。在第1组（n = 3）中，通过更换原始的游离骨瓣来闭合颅骨缺损，并用纤维蛋白胶将复合支架填充残余的裂隙和毛刺孔。在第2组（n = 2）中，仅通过更换原始的游离骨瓣来闭合骨缺损。治疗后三个月，对动物进行了计算机断层扫描和组织学检查。结果：在第1组的所有狗中，缺损几乎被新骨闭合。而在第2组中，缺损处充满了纤维组织而不是骨头。结论：这项研究表明，由β-TCP，胶原蛋白和自体骨碎片与纤维蛋白胶制成的复合支架能够在没有常规固定材料的情况下重建颅骨缺损。

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