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Treatment of squamous cell carcinoma of the retromolar trigone.

机译:磨牙后三角骨的鳞状细胞癌的治疗。

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摘要

OBJECTIVES: Retromolar trigone (RMT) squamous cell carcinoma is uncommon but notorious for poor prognosis. We reviewed our experience in the management of RMT cancer to determine survival rates and to identify prognostic factors. METHODS: Fifty patients with RMT squamous cell carcinoma were treated with surgery and/or radiation or chemoradiation therapy between July 1993 and June 2004 at Chang Gung Memorial Hospital, Taiwan. Patients were followed up for 3 to 106 months (mean, 36 months). There were 6 stage I, 13 stage II, 4 stage II, and 27 stage N patients. RESULTS: The 5-year actuarial survival rate for stage I to N and all stages were 100%, 74.1%, 75%, 43.6%, and 60.6%, respectively. Seventeen (34%) patients had maxilla bone (11 [22%]) or mandible bone (9 [18%]) invasion. Eleven (22%) patients had masticator space involvement. Cervical metastasis rate was 26%. Multivariate analysis revealed that masticator space involvement, neck recurrence, and cervical metastasis were poor prognosticators of survival by order. The maxilla bone was more apt to be involved by RMT cancer than the mandible. Patients with masticator space involvement had a 5-year actuarial survival rate of 22.5% and the mean survival time was only 37.8 months. CONCLUSIONS: RMT squamous cell carcinomas are aggressive tumors. The maxilla is more apt to be involved than the mandible. Deep infiltration of the masticator space and invasion of the maxilla and mandible worsen the prognosis.
机译:目的:磨牙后三角骨(RMT)鳞状细胞癌并不常见,但因预后差而臭名昭著。我们回顾了我们在RMT癌症管理方面的经验,以确定存活率并确定预后因素。方法:1993年7月至2004年6月,在台湾长庚纪念医院接受外科手术和/或放射或化学放射疗法治疗50例RMT鳞状细胞癌患者。对患者进行了3至106个月的随访(平均36个月)。一期患者为6例,二期患者为13例,二期患者为4例,N期患者为27例。结果:I至N期和所有阶段的5年精算生存率分别为100%,74.1%,75%,43.6%和60.6%。十七名(34%)患者上颌骨侵犯(11 [22%])或下颌骨侵犯(9 [18%])。 11名(22%)患者有咀嚼器空间受累。宫颈转移率为26%。多变量分析显示,咀嚼器空间受累,颈部复发和宫颈转移是按顺序生存的不良预后因素。上颌骨比下颌骨更容易被RMT癌累及。咀嚼器空间累及患者的5年精算生存率为22.5%,平均生存时间仅为37.8个月。结论:RMT鳞状细胞癌是侵袭性肿瘤。上颌比下颌更容易受累。咀嚼器间隙的深度浸润以及上颌骨和下颌骨的浸润会恶化预后。

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