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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Laryngotracheal reconstruction with tracheal patch allografts.
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Laryngotracheal reconstruction with tracheal patch allografts.

机译：气管贴片同种异体移植喉气管重建。

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摘要

The capacity of tracheal allotransplants in providing optimal tissues for laryngotracheal repair was studied in an animal model. Segments of cervical trachea could be revascularized completely when wrapped in a receptor fascia flap in immunosuppressed rabbits. In phase I the revascularized tracheas were incised longitudinally and transformed into four different patches after a 14-day revascularization period. The blood supply toward the four patch designs was examined with angiography. The patch designs that showed a vascularization over at least 75% of their mucosal surface area were used in phase II to reconstruct extended anterior laryngotracheal defects. The morphologic characteristics of the tracheal patches when used inside laryngotracheal defects were studied using radiographic, angiographic, and histologic techniques. The revascularized allograft patches that were fully supported by tracheal cartilage were most suitable to repair anterior laryngotracheal defects in this animal study. This model allowed us to define the tissue characteristics necessary for obtaining a combination of primary healing and optimal luminal support in the repair of laryngotracheal defects.
机译：在动物模型中研究了气管同种异体移植物为喉气管修复提供最佳组织的能力。当包裹在免疫抑制兔的受体筋膜瓣中时，可以完全重新血管化颈段。在第一阶段，将经过血运重建的气管纵向切开，并在14天的血运重建期后转变为四个不同的斑块。通过血管造影检查了向四个贴片设计的血液供应。在II期中使用显示至少75％的粘膜表面积血管化的贴片设计来重建扩大的前喉气管缺损。使用放射线照相术，血管造影术和组织学技术研究了气管贴片在喉气管内缺损中使用时的形态学特征。在该动物研究中，完全由气管软骨支撑的血管重建同种异体移植片最适合修复前喉气管缺损。该模型使我们能够定义必要的组织特性，以在喉气管气管缺损的修复中获得主要的愈合和最佳的腔支持。

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