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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Primary treatment of ranula with intracystic injection of OK-432.
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Primary treatment of ranula with intracystic injection of OK-432.

机译：囊内注射OK-432初步治疗肉芽。

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OBJECTIVE: Although surgery is the first choice of therapy for ranula, it was made a hypothesis that ranula can be primarily treated with sclerotherapy from prior evidence. This study examined the effectiveness of intracystic injection of OK-432 for treatment of ranula. METHOD: This prospective clinical study comprised a total of 26 patients with ranula (19 intraoral type; seven plunging type) treated with OK-432 sclerotherapy. Aspirated mucus of ranula was replaced with an equal volume of OK-432 solution of 0.01 mg/mL. The size of ranula was compared before and after sclerotherapy. RESULTS: Twenty of 26 patients (77%) showed a complete response after sclerotherapy: higher in plunging ranula (86%) than in intraoral ranula (74%). Rupture of ranula developed in seven of 19 patients (37%) with intraoral ranula within a few days after injection. The early rupture occurred more frequently in patients having a less-than-marked response and seemed to cause an increase in the total number of OK-432 injections:seven ruptured cases versus 12 nonruptured cases (mean 3.6 versus 1.5, P<.001). Recurrence occurred in two patients during a median follow-up period of 12 months (range, 9-22 mo) after the last injection. There were no major side effects, scarring, or increased morbidity to surgery of the OK-432-injected lesions. CONCLUSION: The intracystic injection of OK-432 is highly effective as a primary treatment modality of ranula.
机译：目的：尽管外科手术是治疗破膜的首选方法，但有一个假设，即根据先前的证据，可以采用硬化疗法对破膜进行主要治疗。这项研究检查了囊内注射OK-432的治疗效果。方法：这项前瞻性临床研究共包括26例用OK-432硬化疗法治疗的肉芽（19例口腔内型; 7例内陷型）。用等体积的0.01 mg / mL的OK-432溶液代替抽出的粘液。在硬化治疗之前和之后比较排泄物的大小。结果：26例患者中有20例（77％）在硬化治疗后显示出完全的反应：切入性粘膜炎（86％）高于口内粘膜炎（74％）。注射后几天内，在19名患者中有7名（37％）出现了口腔破裂。反应较差的患者更容易发生早期破裂，似乎引起OK-432注射总数的增加：破裂病例7例，未破裂病例12例（平均3.6比1.5，P <.001） 。在最后一次注射后的12个月的中位随访期（9-22个月）内，两名患者复发。注射OK-432的病变无严重副作用，疤痕或发病率增加。结论：OK-432囊内注射是一种有效的治疗方法。

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