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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Imaging of the Pediatric Airway Using Optical Coherence Tomography.
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Imaging of the Pediatric Airway Using Optical Coherence Tomography.

机译：使用光学相干断层扫描对小儿气道进行成像。

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OBJECTIVES:: Optical coherence tomography (OCT) is an imaging modality that uses a broadband light source to produce high-resolution cross-sectional images in living tissue (8-20 mum). A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess the utility of OCT technology in characterizing the microanatomy of the pediatric upper aerodigestive tract in vivo. STUDY DESIGN:: Prospective clinical trial. MATERIALS AND METHODS:: Fifteen patients from 1 to 17 years of age underwent surgical endoscopy and OCT for various airway disorders. OCT imaging was performed at a frame rate of 1 Hz using a 1.3-mum broadband light source to produce images 1.6 x 6 mm in vertical and horizontal dimensions. The epithelium, lamina propria, and unique tissue microstructures were visualized and then measured using digital micrometry. Direct comparison of OCT images with endoscopic photography was performed. RESULTS:: Systematic imaging of the oral cavity, oropharynx, hypopharynx, and larynx was performed in all 15 patients. Normal microstructures identified included papillae, ducts, glands, and vessels, whereas pathologic conditions included distinct zones of mature scar, granulation tissue, edema, ulceration, and papillomatosis. Endoscopic photographs were well correlated with OCT images. CONCLUSIONS:: OCT is capable of obtaining high-resolution microanatomy images of pediatric airway in vivo tissue. OCT clearly identifies the epithelium and lamina propria while providing detailed structural information on normal and diseased tissues. OCT is a promising emerging imaging modality for use in current pediatric patient populations.
机译：目的：光学相干断层扫描（OCT）是一种成像方式，使用宽带光源在活体组织（8-20毫米）中产生高分辨率的横截面图像。对儿童气道的正常，良性和病理组织进行了前瞻性研究，以评估OCT技术在表征儿童小儿上消化道的微解剖结构中的用途。研究设计：：前瞻性临床试验。材料与方法：15名1至17岁的患者因各种气道疾病接受了手术内窥镜检查和OCT。使用1.3微米宽带光源以1 Hz的帧频执行OCT成像，以产生垂直和水平尺寸为1.6 x 6 mm的图像。可视化上皮，固有层和独特的组织微观结构，然后使用数字测微仪进行测量。将OCT图像与内窥镜摄影进行直接比较。结果：15例患者均进行了口腔，口咽，下咽和喉的系统成像。确定的正常微结构包括乳头，导管，腺体和血管，而病理状况包括成熟疤痕，肉芽组织，水肿，溃疡和乳头状瘤病的不同区域。内窥镜照片与OCT图像具有很好的相关性。结论：OCT能够获得小儿气道体内组织的高分辨率显微解剖图像。 OCT可以清楚地识别上皮和固有层，同时提供有关正常和患病组织的详细结构信息。 OCT是一种有前途的新兴成像方式，可用于当前的儿科患者人群。

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