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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Breath actuated device improves delivery to target sites beyond the nasal valve.
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Breath actuated device improves delivery to target sites beyond the nasal valve.

机译：呼吸致动装置改善了向鼻瓣以外目标部位的输送。

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OBJECTIVES: The objective was to compare nasal deposition patterns achieved with a conventional hand actuated spray pump and a novel breath actuated bidirectional prototype device housing the same spray pump (OptiMist, OptiNose AS, Oslo, Norway). STUDY DESIGN AND METHODS: The bidirectional delivery device exploits the posterior connection between the nasal passages persisting when the velum automatically closes during oral exhalation. The deposition and clearance patterns achieved with the two devices were compared in nine healthy subjects by scintigraphy after administration of Tc-aerosols. RESULTS: Compared with traditional spray pump delivery, the OptiMist device provided significantly (P < .004) larger initial and cumulative deposition (area under the deposition vs. time curve) in the upper posterior segment of the nasal passage, housing the sinus ostia and the olfactory region, and significantly lower deposition (P < .004) in the anterior segment, lined by nonciliated squamous epithelium. Furthermore, intersubject reproducibility of the initial and cumulative deposition was higher for the OptiMist device both in the upper posterior segment and the entire nose. CONCLUSIONS: Compared with a spray pump, the novel breath actuated bidirectional device provides significantly larger deposition in the clinically important regions beyond the nasal valve and reduced anterior deposition. These striking differences provide new opportunities for improved therapy of chronic rhinosinusitis and polyposis as well as extended use of the nose for delivery of drugs from the nose into the brain.
机译：目的：目的是比较传统的手动喷雾泵和装有相同喷雾泵的新型呼吸双向原型设备（OptiMist，OptiNose AS，奥斯陆，挪威）获得的鼻腔沉积方式。研究设计与方法：双向输送装置利用了鼻腔通道之间的后部连接，当口腔呼气时膜自动关闭时，鼻腔通道持续存在。服用Tc气雾剂后，通过闪烁显像比较了9位健康受试者在这两种设备上获得的沉积和清除方式。结果：与传统的喷雾泵输送相比，OptiMist装置在鼻道的上后段提供了较大的（P <.004）较大的初始和累积沉积（沉积与时间曲线下的面积），并容纳了窦口和鼻窦。嗅觉区域，并在前段显着降低的沉积（P <.004），内衬无纤毛鳞状上皮。此外，OptiMist装置在后上段和整个鼻子上初始和累积沉积物的受试者间可重复性都较高。结论：与喷雾泵相比，新型呼吸致动双向装置可在鼻瓣以外的临床重要区域提供明显更大的沉积，并减少前路沉积。这些惊人的差异为改善慢性鼻-鼻窦炎和息肉病的治疗方法以及扩大使用鼻子从鼻子到大脑的药物输送提供了新的机会。

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