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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Association of Extraesophageal Reflux Disease and Sinonasal Symptoms: Prevalence and Impact on Quality of Life.
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Association of Extraesophageal Reflux Disease and Sinonasal Symptoms: Prevalence and Impact on Quality of Life.

机译：食管外反流疾病和鼻鼻症状的关联：患病率及其对生活质量的影响。

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OBJECTIVES:: The purpose of this study was to investigate the prevalence of extraesophageal reflux disease symptoms and their association with sinonasal disorders within a general sample of adults in our community and to determine how these conditions affect perception of general health, sinus-related quality of life (QOL), and perception of reflux and digestive function. STUDY DESIGN/METHODS:: A community-dwelling sample of 1,878 adults completed symptom and QOL surveys in a two-stage prospective design: an initial screening questionnaire (n = 1,878) and disease-specific (sinus and reflux/digestion) and general health-related QOL instruments (n = 1,073). Demographic and response data were summarized and analyzed for prevalence and correlations among data sets. RESULTS:: Sinonasal symptoms were reported in 71% of subjects who completed the initial screening questionnaire, and reflux-related symptoms were reported by 59% of respondents. The co-occurrence of sinonasal and reflux symptoms was reported by 45% of respondents. Subjects with both sinonasal and reflux symptoms scored significantly worse on the disease-specific and general physical and mental QOL scales than subjects with only reflux or sinonasal symptoms or no symptoms. CONCLUSIONS:: Symptoms associated with inflammatory sinonasal disorders and gastroesophageal reflux disease are common in the general U.S. adult population and co-occur in the same individuals to a greater degree than can be attributed to chance alone. Co-occurrence was found to be associated with significant declines in both disease-specific and general physical and mental QOL. This finding has implications with regard to pathogenesis and treatment of these disorders.
机译：目的：本研究的目的是调查我们社区普通成年人中食管外反流疾病症状的患病率及其与鼻窦疾病的关系，并确定这些状况如何影响人们对一般健康的认识以及与鼻窦相关的质量生活（QOL），以及对反流和消化功能的感知。研究设计/方法：：社区居住的1878名成年人样本通过两阶段的前瞻性设计完成了症状和QOL调查：初始筛查问卷（n = 1878）和针对特定疾病（鼻窦和反流/消化不良）和总体健康状况的研究相关的QOL工具（n = 1,073）。汇总并分析了人口统计和响应数据，以了解数据集之间的普遍性和相关性。结果：完成初次筛查问卷的受试者中有71％报告有鼻鼻症状，有59％的应答者报告了与反流有关的症状。据报道45％的受访者同时出现鼻窦和反流症状。鼻窦和反流症状的受试者在疾病特异性和一般的身体和精神QOL量表上的得分明显低于仅反流或鼻窦症状或无症状的受试者。结论：与炎症性鼻窦疾病和胃食管反流疾病有关的症状在美国普通成年人中很常见，并且在同一个体中并发的程度要大于仅因偶然性而引起的程度。发现同时存在与特定疾病以及一般的身心QOL显着下降有关。该发现对这些疾病的发病机理和治疗具有影响。

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