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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Structural variations in a single hyaluronan derivative significantly alter wound-healing effects in the rabbit maxillary sinus.
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Structural variations in a single hyaluronan derivative significantly alter wound-healing effects in the rabbit maxillary sinus.

机译：单个透明质酸衍生物的结构变化显着改变了兔上颌窦的伤口愈合效果。

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BACKGROUND: Biomaterials based on hyaluronan (HA) are currently used after sinus surgery but have not been found to decrease scarring or enhance wound healing. Chemical composition of these modified HA molecules may impact their biological and clinical effects. OBJECTIVE: To analyze chemical variations of a single crosslinked HA-based hydrogel, chemically modified thiolated HA (CMHA-SX). METHODS: Four different components of the hydrogel composition were altered, yielding 54 variations. These were subjected to biomechanical testing, and then potential clinically relevant variations were further tested for swelling and degradation characteristics. Using a rabbit maxillary sinus model, the ability of the material variations to stent a neo-ostium was tested. Histologic measures were also assessed. Biomechanical and biological effects were correlated. RESULTS: Minor compositional changes had profound biomechanical and biological effects. Swelling and rate of enzymatic degradation were closely related. CMHA-SX hydrogels that were the most effective stents in maintaining the neo-ostium also generated the lowest level of acute inflammation, as determined by histology. CONCLUSIONS: Chemical composition has a significant impact on the clinical potential of modified HA materials. Histocompatibility appears to most significantly affect ostium preservation. SIGNIFICANCE: Different CMHA-SX hydrogels perform differently in vivo, even when the chemical compositions are quite similar. Objective prospective testing of modified HA materials should precede their clinical use in sinus surgery.
机译：背景：基于透明质酸（HA）的生物材料目前在鼻窦手术后使用，但尚未发现能减少疤痕或促进伤口愈合。这些修饰的HA分子的化学成分可能会影响其生物学和临床效果。目的：分析单交联的基于HA的水凝胶的化学变化，化学修饰的硫醇化HA（CMHA-SX）。方法：改变了水凝胶组成的四个不同成分，产生了54种变化。对它们进行生物力学测试，然后针对潜在的临床相关变异进一步测试其溶胀和降解特性。使用兔上颌窦模型，测试材料变化对新口支架的能力。还评估了组织学指标。生物力学和生物效应是相关的。结果：微小的成分变化具有深远的生物力学和生物学影响。溶胀与酶促降解速率密切相关。 CMHA-SX水凝胶是维持新生血管最有效的支架，根据组织学确定，其产生的急性炎症水平也最低。结论：化学成分对改性HA材料的临床潜力具有重大影响。组织相容性似乎最明显地影响了口的保存。意义：即使化学成分非常相似，不同的CMHA-SX水凝胶在体内的表现也不同。改性HA材料的客观前瞻性测试应在其在鼻窦手术中的临床应用之前进行。

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