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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Effect of N-acetylcysteine on Carboplatin-induced ototoxicity and nitric oxide levels in a rat model.
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Effect of N-acetylcysteine on Carboplatin-induced ototoxicity and nitric oxide levels in a rat model.

机译：N-乙酰半胱氨酸对卡铂诱导的大鼠耳毒性和一氧化氮水平的影响。

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OBJECTIVE:: The aim of the present study is to investigate the effect of N-acetylcysteine (NAC) given 30 minutes before carboplatin administration on carboplatin-induced ototoxicity and nitric oxide (NO) levels in a rat model. STUDY DESIGN:: Animal study. METHODS:: Eighteen Sprague-Dawley rats were divided into three groups that each contained six animals. Intraperitoneal injection of physiologic saline was performed in group 1 twice with an interval of 30 minutes. Group 2 was treated with a single bolus administration of carboplatin at a dose of 256 mg/kg 30 minutes after the intraperitoneal injection of physiologic saline. Group 3 was treated with a single bolus administration of carboplatin at a dose of 256 mg/kg 30 minutes after the intraperitoneal injection of NAC at a dose of 400 mg/kg. Pretreatment and posttreatment distortion product otoacoustic emissions (DPOAE) were performed in rats from all groups. Then, the animals were sacrificed on the fourth day, and cochlear tissue NO and glutathione peroxidase (GSH-Px) levels were measured. RESULTS:: The comparison of pre- and posttreatment DPOAE responses did not demonstrate any significant changes for groups 1 and 3. Results of group 2 showed a decrease of the DPOAE amplitude. Cochlear NO levels were significantly higher in rats treated with carboplatin than in controls and in those treated with carboplatin plus NAC (P < .05). Cochlear GSH-Px levels were higher in rats treated with carboplatin plus NAC than in those treated with carboplatin, but the difference did not reach statistical significance (P = .079). CONCLUSIONS:: The present study showed that carboplatin at higher doses induced hearing loss and increased NO levels in the cochlea of rats. NAC appears to have a protective effect against carboplatin-induced ototoxicity, which may be related to its inhibitory effect on NO production.
机译：目的：本研究的目的是研究在给予卡铂前30分钟给予N-乙酰半胱氨酸（NAC）对卡铂诱导的耳毒性和一氧化氮（NO）水平的影响。研究设计：：动物研究。方法：将18只Sprague-Dawley大鼠分为三组，每组六只动物。在第1组中两次腹膜内注射生理盐水，间隔为30分钟。腹膜内注射生理盐水后30分钟，单次推注卡铂以256 mg / kg的剂量治疗第2组。腹膜内注射NAC 400 mg / kg后30分钟，单次推注卡铂以256 mg / kg的剂量治疗第3组。在所有组的大鼠中进行预处理和后处理失真产物耳声发射（DPOAE）。然后，在第四天处死动物，并测量耳蜗组织NO和谷胱甘肽过氧化物酶（GSH-Px）水平。结果：治疗前和治疗后DPOAE反应的比较未显示第1组和第3组有任何显着变化。第2组的结果显示DPOAE振幅降低。卡铂治疗的大鼠的耳蜗NO水平明显高于对照组和卡铂加NAC治疗的大鼠（P <.05）。卡铂加NAC治疗的大鼠耳蜗GSH-Px水平高于卡铂治疗的大鼠，但差异无统计学意义（P = .079）。结论：本研究表明，较高剂量的卡铂可引起大鼠耳蜗听力下降和NO水平升高。 NAC似乎对卡铂诱导的耳毒性有保护作用，这可能与其对NO产生的抑制作用有关。

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