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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Otoprotective effects of dexamethasone in the management of pneumococcal meningitis: an animal study.
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Otoprotective effects of dexamethasone in the management of pneumococcal meningitis: an animal study.

机译：地塞米松在肺炎球菌性脑膜炎管理中的耳保护作用：一项动物研究。

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OBJECTIVE: To determine whether treating pneumococcal meningitis with a combined antibiotic and steroid regime will prevent cochlear damage, a common pneumococcal meningitis side effect. STUDY DESIGN: Prospective animal study. METHODS: Gerbils were randomly assigned to three experimental groups. Animals in group 1 received intrathecal saline injections. Animals in groups 2 and 3 received intrathecal injections of Streptococcus pneumoniae to induce meningitis. Group 2 was treated for 7 days with intraperitoneal penicillin injections (48,000 units). Animals from group 3 received intraperitoneal dexamethasone (0.5 mg/kg) injections for 4 days in addition to 7 days of intraperitoneal penicillin. Three months after the meningitis was induced, the animals' cochlear functions were determined using auditory brainstem responses (ABRs). After measuring cochlear function, the animals were sacrificed for cochlear histopathology. Spiral ganglion cell densities at Rosenthal's canal were determined. RESULTS: ABR thresholds were significantly elevated in animals from group 2 when compared with the animals in groups 1 and 3 (P < .05). ABR thresholds for animals from group 3 and group 1 were similar (P > .05). Damage of cochlear structures was detected in animals from group 2. The degree of the damage varied: one animal in group 2 had no identifiable hair cells and pillar cells and showed damage of the tectorial membrane. Spiral ganglion density in the basal turn was significantly less in animals from group 2 when compared with controls (P < .05). Although spiral ganglion cell density was less in the dexamethasone-treated group (group 3) when compared with group 1 (control group), but greater than observed in animals treated with antibiotics only (group 2), the differences were statistically not significant (P > .5). Nuclear diameters of the spiral ganglion cells decreased on average from 7.24 +/- 0.48 microm (group 1) to 6.28 +/- 0.76 microm (group 3, animals that received dexamethasone) to 5.57 +/- 0.82 microm (group 2, animals that received antibiotics only). Differences were significant (P < .05). Differences in stria vascularis thickness were not significant among the animals. CONCLUSION: Dexamethasone has a protective effect on the cochlea when given together with antibiotics in the treatment of pneumococcal meningitis.
机译：目的：确定抗生素和类固醇联合治疗肺炎球菌性脑膜炎是否可以预防耳蜗损伤，这是肺炎球菌性脑膜炎的常见副作用。研究设计：前瞻性动物研究。方法：将沙鼠随机分为三个实验组。第1组的动物接受鞘内注射盐水。第2组和第3组的动物接受鞘内注射肺炎链球菌诱导脑膜炎。第2组用腹膜内青霉素注射液（48,000单位）治疗7天。除腹膜内青霉素7天外，第3组的动物还接受腹膜内地塞米松（0.5 mg / kg）注射4天。诱发脑膜炎三个月后，使用听觉脑干反应（ABR）确定动物的耳蜗功能。在测量耳蜗功能后，处死动物以进行耳蜗组织病理学检查。确定了Rosenthal运河的螺旋神经节细胞密度。结果：与第1组和第3组的动物相比，第2组的动物的ABR阈值显着升高（P <.05）。第3组和第1组动物的ABR阈值相似（P> 0.05）。在第2组的动物中检测到耳蜗结构的损伤。损伤的程度各不相同：第2组中的一只动物没有可识别的毛细胞和柱状细胞，并显示了冠状膜的损伤。与对照组相比，第2组动物的基底转弯处的螺旋神经节密度显着降低（P <.05）。尽管与第1组（对照组）相比，地塞米松治疗组（第3组）的螺旋神经节细胞密度较小，但比仅接受抗生素治疗的动物（第2组）的螺旋神经节细胞密度高，但差异无统计学意义（P > .5）。螺旋神经节细胞的核直径平均从7.24 +/- 0.48微米（第1组）降低至6.28 +/- 0.76微米（第3组，接受地塞米松的动物）至5.57 +/- 0.82微米（第2组，符合条件的动物）仅接受抗生素）。差异是显着的（P <.05）。在动物之间，血管纹的厚度差异不显着。结论：地塞米松与抗生素一起治疗肺炎球菌性脑膜炎对耳蜗具有保护作用。

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