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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Changes of extremity and laryngeal muscle electromyographic amplitudes after intravenous administration of vecuronium.
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Changes of extremity and laryngeal muscle electromyographic amplitudes after intravenous administration of vecuronium.

机译：静脉注射维库溴铵后肢体和喉肌肌电图振幅的变化。

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OBJECTIVES: To compare electromyographic (EMG) amplitude changes in extremity and laryngeal muscles after vecuronium administration and study the effects of topical lidocaine on laryngeal EMG in a swine model. STUDY DESIGN: Prospective animal study. METHODS: Electrically evoked EMG activities were recorded from the vocalis muscles (directly and via an EMG endotracheal tube) and from the flexor digitorum muscles before and after intravenous vecuronium administration. EMG amplitudes were followed for 30 minutes after vecuronium injection together with monitoring of limb twitches to train-of-four stimulation. The testing was repeated after a 30-minute wash-out period and with topical lidocaine. RESULTS: EMG amplitude recovery occurred sooner and more quickly in flexor digitorum muscle than in vocalis muscles. Reappearance of four twitches corresponded to EMG amplitude recovery to about 80% of the baseline in flexor digitorum muscles and to about half-baseline size in vocalis muscles. EMG amplitudes were generally lower at the start of the second round testing than the first round, with somewhat slower recovery in vocalis muscles. CONCLUSIONS: In contrast to reports by others in human studies, extremity muscles seem to be more resistant to vecuronium at 0.1 mg/kg than laryngeal muscles in the swine. Reappearance of four twitches corresponds to 50% of laryngeal EMG recovery and indicates adequate condition for monitoring electrically evoked laryngeal EMG activities. This study is inconclusive regarding the effects of topically applied lidocaine on laryngeal EMG amplitudes. Translation of these data to humans should be done with caution.
机译：目的：比较施用维库溴铵后肢体和喉肌的肌电图（EMG）振幅变化，并研究局部利多卡因对猪模型中喉肌电图的影响。研究设计：前瞻性动物研究。方法：静脉注射维库溴铵前后，从声带肌肉（直接和通过EMG气管导管）和指趾屈肌记录电诱发的EMG活动。注射维库溴铵后，监测30分钟的EMG振幅，并监测肢体抽搐以进行四次刺激。在30分钟的冲洗时间后，使用局部利多卡因重复进行测试。结果：屈指趾肌的EMG振幅恢复发生的时间比声带肌更快。四个抽搐的重新出现对应于屈肌指肌的EMG振幅恢复至基线的约80％，声带肌的恢复至约基线的一半。在第二轮测试开始时，EMG振幅通常低于第一轮，声带肌肉的恢复速度稍慢。结论：与其他人体研究报告相比，四肢肌肉对猪维库溴铵的抵抗力似乎高出0.1 mg / kg。再次出现四次抽搐，相当于喉肌电图恢复的50％，并表明有足够的条件来监测电诱发的喉肌电图活动。对于局部应用利多卡因对喉肌电图振幅的影响，这项研究尚无定论。将这些数据转换为人类时应格外小心。

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