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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial.
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Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial.

机译：选择性颈淋巴清扫术和减轻放射强度的口咽癌术后化疗：宾夕法尼亚大学经口机器人手术试验的子集分析。

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OBJECTIVES/HYPOTHESIS: The purpose of this study was to determine the regional recurrence rate of node-positive oropharyngeal squamous cell carcinoma (OPSCC) in patients undergoing transoral robotic surgery (TORS) and selective neck dissection (SND) followed by observation, radiation, or concurrent chemoradiation. STUDY DESIGN: A prospective, phase I, single-arm study was conducted. All OPSCC patients who voluntarily participated in a surgical trial with TORS and SND at an academic tertiary referral center from May 2005 to July 2007 were included. METHODS: Thirty-one patients with previously untreated OPSCC undergoing TORS and SND (29 unilateral and two bilateral) were included. There were 29 males and two females, with ages ranging from 36 to 76 years (median = 55 years) with one palate, one lateral wall, 17 tonsil, 11 base of tongue, and one vallecula primary tumor classified as follows: T1 (n = 9, 29%), T2 (n = 15, 48.4%), T3 (n = 7, 22.6%), N0 (n = 6, 19.4%), N1 (n = 15, 48.4%), N2b (n = 10, 32.3%), and N2c (n = 1, 3.2%). There were three stage I (9.7%), two stage II (6.5%), 15 stage III (48.4%) and 11 stage IVa (35.5%) patients. Twenty-two patients were treated postoperatively with adjuvant therapy (12 radiation alone and 12 combined radiation and chemotherapy). Primary outcome measured was regional recurrence rate. RESULTS: There was one regional recurrence on the contralateral, non-operated neck and one distant recurrence among the 31 patients who underwent SND. CONCLUSIONS: SND after TORS resection of primary OPSCC enables the use of selective and deintensified adjuvant therapy to reduce regional recurrence rates.
机译：目的/假设：这项研究的目的是确定经口机器人手术（TORS）和选择性颈淋巴清扫术（SND），随后进行观察，放射或放射治疗的淋巴结阳性口咽鳞状细胞癌（OPSCC）的区域复发率同时放化疗。研究设计：进行了前瞻性，I期单臂研究。纳入了所有自2005年5月至2007年7月在学术三级转诊中心自愿参加TORS和SND外科手术试验的OPSCC患​​者。方法：31例先前未接受过OPSCC治疗的患者接受了TORS和SND（29例单侧和2例双侧）。男29例，女2例，年龄在36-76岁之间（中位数= 55岁），其上颚，侧壁1个，扁桃体17个，舌根11个，one部原发性肿瘤1个，分类如下：T1（n = 9、29％），T2（n = 15、48.4％），T3（n = 7、22.6％），N0（n = 6、19.4％），N1（n = 15、48.4％），N2b（n = 10、32.3％）和N2c（n = 1、3.2％）。一期为三期（9.7％），二期为二期（6.5％），三期为十五期（48.4％），十一期为Ⅳa期（35.5％）。术后接受辅助治疗的22例患者（单独放疗12例，放化疗联合12例）。测得的主要结局为区域复发率。结果：31例接受SND的患者中，对侧，非手术性颈部有1例局部复发，远处复发1例。结论：原发性OPSCC的TORS切除后的SND使选择性和去强化辅助治疗的使用降低了区域复发率。

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