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首页> 外文期刊>The American Journal of Cardiology >Effect of blood glucose concentrations on admission in non-diabetic versus diabetic patients with first acute myocardial infarction on short- and long-term mortality (from the MONICA/KORA Augsburg Myocardial Infarction Registry).
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Effect of blood glucose concentrations on admission in non-diabetic versus diabetic patients with first acute myocardial infarction on short- and long-term mortality (from the MONICA/KORA Augsburg Myocardial Infarction Registry).

机译：血糖浓度对初发急性心肌梗塞的非糖尿病患者和糖尿病患者入院对短期和长期死亡率的影响（来自MONICA / KORA Augsburg心肌梗塞登记处）。

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The aim of this study was to investigate the association between increased admission glucose in nondiabetic (ND) patients and in patients with type 2 diabetes mellitus (T2DM) with first acute myocardial infarctions (AMIs) and 28-day as well as 1- and 3-year case fatality. The Monitoring Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) myocardial infarction registry database in Augsburg, Germany, was used, and 1,631 patients without and 659 patients with T2DM (aged 25 to 74 years) who were admitted from 1998 to 2003 with first AMIs were included. Mortality follow-up was carried out in 2005. ND patients with AMIs with admission glucose >152 mg/dl (top quartile) compared with those in the bottom quartile had an odds ratio of 2.82 (95% confidence interval [CI] 1.30 to 6.12) for death within 28 days after multivariate adjustment; correspondingly, patients with T2DM with admission glucose >278 mg/dl (top quartile) compared with those in the bottom quartile (<152 mg/dl) showed a nonsignificantly increased odds ratio of 1.45 (95% CI 0.64 to 3.31). After the exclusion of patients who died within 28 days, a nonsignificantly increased relative risk (RR) was seen between admission blood glucose and 1-year mortality in ND subjects (RR 2.71, 95% CI 0.90 to 8.15), whereas no increased RR was found in subjects with diabetes (RR 0.99, 95% CI 0.34 to 2.82). After 3 years, there was no increased risk for death in patients with high admission blood glucose levels, neither for ND patients nor for those with T2DM. In conclusion, elevated admission blood glucose is associated with increased short-term mortality risk in patients with AMIs, particularly in ND subjects. These patients constitute a high-risk group needing aggressive, comprehensive polypharmacotherapy.
机译：这项研究的目的是调查非糖尿病（ND）患者和2型糖尿病（T2DM）合并首次急性心肌梗塞（AMI）和28天以及1天和3天患者的入院血糖升高之间的相关性年病死率。使用了德国奥格斯堡的心血管疾病监测趋势和决定因素（MONICA）/奥格斯堡地区合作健康研究（KORA）心肌梗死注册数据库，分别对1,631例无T2DM的患者和659例T2DM进行了研究（年龄在25至74岁之间） ）从1998年至2003年因首次AMI入院。死亡率随访于2005年进行。AMI入院葡萄糖> 152 mg / dl（上四分位数）的ND患者与下四分位数的ND患者的比值比为2.82（95％置信区间[CI] 1.30至6.12） ）在进行多变量调整后的28天内死亡;相应地，与最低四分位数（<152 mg / dl）相比，入院葡萄糖> 278 mg / dl（最高四分位数）的T2DM患者的比值比无明显增加，为1.45（95％CI为0.64至3.31）。排除在28天之内死亡的患者后，ND患者的入院血糖与1年死亡率之间的相对危险度（RR）显着增加（RR 2.71，95％CI 0.90 to 8.15），而RR并未增加在糖尿病患者中发现（RR 0.99，95％CI 0.34至2.82）。 3年后，无论是ND患者还是T2DM患者，高入院血糖水平的患者死亡风险均没有增加。总之，入院血糖升高与AMI患者（尤其是ND受试者）的短期死亡风险增加相关。这些患者构成了需要积极进行全面综合药物治疗的高危人群。

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