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首页> 外文期刊>The American Journal of Cardiology >Gender-Specific short and long-term mortality in diabetic versus nondiabetic patients with incident acute myocardial infarction in the reperfusion era (the MONICA/KORA Myocardial Infarction Registry).
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Gender-Specific short and long-term mortality in diabetic versus nondiabetic patients with incident acute myocardial infarction in the reperfusion era (the MONICA/KORA Myocardial Infarction Registry).

机译：在再灌注时代，发生糖尿病和非糖尿病并发急性心肌梗塞的患者的性别和短期死亡率（MONICA / KORA心肌梗塞登记册）。

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摘要

The aim of this study was to investigate gender-specific short- and long-term mortalities after a first acute myocardial infarction (AMI) in patients with and without diabetes mellitus (DM). The study was based on 505 men and 196 women with DM and 1,327 men and 415 women without DM consecutively hospitalized with a first-ever AMI from January 1998 to December 2003 recruited from a population-based MI registry. Patients were followed until December 31, 2005 (median follow-up time 4.3 years). In men and women, no significantly independent association between DM and short-term mortality was observed. After multivariable adjustment odds ratios (95% confidence intervals [CIs]) for 28-day case fatality were 1.45 (95% CI 0.90 to 2.34) in men with DM compared to men without DM and 1.44 (95% CI 0.66 to 3.15) in women with DM compared to women without DM. Conversely, in 28-day AMI survivors DM was significantly associated with long-term mortality in age-adjusted analyses, in which men with DM had a hazard ratio (HR) of 1.57 (95% CI 1.18 to 2.10) for all-cause mortality compared to non-DM men; the corresponding HR in women with DM was 2.91 (95% CI 1.82 to 4.65). After multivariable adjustment the strong association in women with DM remained significant (HR 2.56, 95% CI 1.53 to 4.27); however, in men with DM it became borderline significant (HR 1.36, 95% CI 1.00 to 1.85). In conclusion, short-term mortality was not significantly increased in men and women with DM after a first-ever AMI, although estimates were relatively high, indicating a possible relation. However, long-term mortality was higher in patients with AMI and DM, particularly in women.
机译：这项研究的目的是调查患有和不患有糖尿病（DM）的患者在首次急性心肌梗塞（AMI）后特定于性别的短期和长期死亡率。该研究基于从1998年1月至2003年12月从基于人群的MI登记处招募的有史以来首次有AMI的505名男性和196名患有DM的女性和1,327名男性和415名无DM的女性连续住院。随访患者至2005年12月31日（平均随访时间4.3年）。在男性和女性中，未观察到糖尿病与短期死亡率之间存在明显的独立关联。经过多变量调整后，患有DM的男性与未患有DM的男性相比，患有DM的男性28天病死率的比值比（95％置信区间[CIs]）为1.45（95％CI 0.90至2.34），而没有DM的男性为1.44（95％CI 0.66-3.15）。患有DM的女性与没有DM的女性相比。相反，在经过年龄调整的分析中，在AMI的28天中，DM与长期死亡率显着相关，其中DM男性的全因死亡率危险比（HR）为1.57（95％CI 1.18至2.10）。与非DM男性相比DM女性的相应HR为2.91（95％CI为1.82至4.65）。经过多变量调整后，糖尿病女性的强关联仍然显着（HR 2.56，95％CI 1.53至4.27）;然而，在患有DM的男性中，这变得非常重要（HR 1.36，95％CI 1.00至1.85）。结论是，有史以来首次有AMI的DM男性和女性的短期死亡率没有显着增加，尽管估计值相对较高，表明可能存在相关性。但是，AMI和DM患者的长期死亡率较高，尤其是女性。

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