...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Comparison of Changes in Global Longitudinal Peak Systolic Strain After ST-Segment Elevation Myocardial Infarction in Patients With Versus Without Diabetes Mellitus
【24h】

Comparison of Changes in Global Longitudinal Peak Systolic Strain After ST-Segment Elevation Myocardial Infarction in Patients With Versus Without Diabetes Mellitus

机译：无糖尿病患者与ST段抬高型心肌梗死后全球纵峰收缩应变变化的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Global longitudinal strain (GLS) measured by 2-dimensional longitudinal speckle-tracking echocardiography may be a more sensitive measure of left ventricular (LV) mechanics than conventional LV ejection fraction (EF) to characterize adverse post-ST-segment elevation myocardial infarction (STEMI) remodeling. The aim of the present evaluation was to compare changes in LV GLS in patients with versus without diabetes after the first STEMI. Patients with first STEMI and diabetes (n = 143; age 64 +/- 12 years; 68% men; 50% left anterior descending artery as culprit vessel) and 290 patients with first STEMI and without diabetes matched on age, gender, and infarct location were included. LV volumes and function and 2-dimensional LV GLS were measured after primary percutaneous coronary intervention (baseline) and at 6-month follow-up. At baseline, patients with and without diabetes had similar LVEF (46.8 +/- 0.7% vs 48.0 +/- 0.5%, p = 0.19) and infarct size (peak cardiac troponin T: 3.1 [1.2 to 6.5] vs 3.7 [1.3 to 7.3] mu g/l, p = 0.10; peak creatine phosphokinase:1,120 [537 to 2,371] vs 1,291 [586 to 2,613] U/l, p = 0.17), whereas LV GLS was significantly more impaired in diabetic patients (-13.7 +/- 0.3% vs -15.3 +/- 0.2%, p < 0.001). Although diabetic patients showed an improvement in LVEF over time similar to nondiabetic patients (52.0 +/- 0.8% vs 53.1 +/- 0.6%, p = 0.25), GLS remained more impaired at 6-month follow-up compared with nondiabetic patients (-15.8 +/- 0.3% vs -17.3 +/- 0.2%, p < 0.001). After adjusting for clinical and echocardiographic characteristics, diabetes was independently associated with changes in GLS from baseline to 6-month follow-up (beta 1.41, 95% confidence interval 0.85 to 1.96, p < 0.001). In conclusion, after STEMI, diabetic patients show more impaired LV GLS at both baseline and follow-up compared with a matched group of patients without diabetes, despite having similar infarct size and LVEF at baseline and follow-up. (C) 2015 Elsevier Inc. All rights reserved.
机译：通过二维纵向散斑跟踪超声心动图测量的总纵向应变（GLS）可能比传统的LV射血分数（EF）更敏感地测量左心室（LV）力学，以表征不良的ST段抬高后心肌梗死（STEMI） ）重塑。本评估的目的是比较首次STEMI后有糖尿病和无糖尿病患者的LV GLS的变化。初发STEMI和糖尿病的患者（n = 143; 64 +/- 12岁;男性; 68％;左前降支为罪犯血管）; 290例初发STEMI且无糖尿病的患者，其年龄，性别和梗塞相匹配位置都包括在内。在初次经皮冠状动脉介入治疗（基线）后和随访6个月时，测量左室容量和功能以及二维左室GLS。在基线时，有无糖尿病的患者的LVEF（46.8 +/- 0.7％vs 48.0 +/- 0.5％，p = 0.19）和梗死面积相似（峰值心肌肌钙蛋白T：3.1 [1.2至6.5] vs 3.7 [1.3至1.3 7.3]μg / l，p = 0.10;峰值肌酸磷酸激酶：1,120 [537至2,371] vs 1,291 [586至2,613] U / l，p = 0.17），而糖尿病患者的LV GLS明显受损（-13.7） +/- 0.3％与-15.3 +/- 0.2％，p <0.001）。尽管糖尿病患者的LVEF随时间的推移与非糖尿病患者相似（52.0 +/- 0.8％vs 53.1 +/- 0.6％，p = 0.25），但与非糖尿病患者相比，GLS在6个月的随访中仍然受损更大（ -15.8 +/- 0.3％与-17.3 +/- 0.2％，p <0.001）。在调整了临床和超声心动图特征后，糖尿病与从基线到6个月随访的GLS变化独立相关（β1.41，95％置信区间0.85至1.96，p <0.001）。总之，在STEMI后，尽管基线和随访时梗死面积和LVEF相似，但与非糖尿病患者相比，糖尿病患者的基线和随访时LV GLS受损更大。 （C）2015 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号