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首页> 外文期刊>The American Journal of Cardiology >Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)
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Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

机译：主动脉瓣钙与慢性肾脏病的关系（来自慢性肾功能不全队列研究）

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Although subjects with chronic kidney disease (CKD) are at markedly increased risk for cardiovascular mortality, the relation between CKD and aortic valve calcification has not been fully elucidated. Also, few data are available on the relation of aortic valve calcification and earlier stages of CKD. We sought to assess the relation of aortic valve calcium (AVC) with estimated glomerular filtration rate (eGFR), traditional and novel cardiovascular risk factors, and markers of bone metabolism in the Chronic Renal Insufficiency Cohort (CRIC) Study. All patients who underwent aortic valve scanning in the CRIC study were included. The relation between AVC and eGFR, traditional and novel cardiovascular risk factors, and markers of calcium metabolism were analyzed using both unadjusted and adjusted regression models. A total of 1,964 CRIC participants underwent computed tomography for AVC quantification. Decreased renal function was independently associated with increased levels of AVC (eGFR 47.11, 44.17, and 39 ml/min/1.73 m(2), respectively, p <0.001). This association persisted after adjusting for traditional, but not novel, AVC risk factors. Adjusted regression models identified several traditional and novel risk factors for AVC in patients with CKD. There was a difference in AVC risk factors between black and nonblack patients. In conclusion, our study shows that eGFR is associated in a dose-dependent manner with AVC in patients with CKD, and this association is independent of traditional cardiovascular risk factors. (C) 2015 Elsevier Inc. All rights reserved.
机译：尽管患有慢性肾脏疾病（CKD）的受试者罹患心血管疾病的风险显着增加，但尚未完全阐明CKD与主动脉瓣钙化之间的关系。此外，关于主动脉瓣钙化与CKD早期的关系的数据很少。在慢性肾功能不全队列研究中，我们试图评估主动脉瓣钙（AVC）与估计的肾小球滤过率（eGFR），传统和新型心血管危险因素以及骨代谢标志物之间的关系。包括所有在CRIC研究中接受主动脉瓣扫描的患者。使用未调整和调整后的回归模型分析了AVC和eGFR，传统和新型心血管危险因素以及钙代谢指标之间的关系。共有1,964名CRIC参与者接受了计算机断层扫描以进行AVC量化。肾功能降低与AVC水平升高独立相关（eGFR 47.11、44.17和39 ml / min / 1.73 m（2），分别为p <0.001）。在调整了传统但非新颖的AVC危险因素后，这种关联仍然存在。调整后的回归模型确定了CKD患者AVC的几种传统和新型危险因素。黑人和非黑人患者之间的AVC危险因素有所不同。总之，我们的研究表明，eGFR与CKD患者的AVC呈剂量依赖性，并且与传统的心血管危险因素无关。 （C）2015 Elsevier Inc.保留所有权利。

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