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首页> 外文期刊>The American Journal of Cardiology >Comparison of the incidence of de novo solid malignancies after heart transplantation to that in the general population.
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Comparison of the incidence of de novo solid malignancies after heart transplantation to that in the general population.

机译：心脏移植后从头实体恶性肿瘤发生率与一般人群相比。

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An increased incidence of lymphomas and skin cancers has been shown in heart transplant recipients compared with the general population. However, the incidence of de novo solid tumors in heart transplant recipients has not been compared with the general population. Accordingly, 851 consecutive adult heart transplant recipients at a single large center were followed up from January 1, 1994, to May 31, 2007, to determine the incidence and type of de novo solid-tumor malignancies. The observed incidence of each cancer type was compared with the expected incidence from the Surveillance Epidemiology End Result database, matching for age, gender, and race. Observed counts divided by expected counts yielded a standardized incidence ratio (SIR), which was tested for significance. Of 851 patients, 73 (8.6%) developed de novo solid-tumor malignancies. Sixty men (83.3%) and 12 women (16.7%) aged 58 +/- 8 years at transplantation were given a diagnosis of cancer at age 62 +/- 8 years. Cancers were divided into 22 categories, and the 3 most frequent cancers were prostate (22), lung (8), and breast (6). SIRs were increased for cervical cancer (SIR 14.3, 95% confidence interval 1.7 to 51.5) and thyroid cancer (SIR 7.7, 95% confidence interval 1.6 to 22.5). Logistic regression showed that age and retransplantation were significant risk factors for cancer. In conclusion, heart transplant recipients did not have a significantly increased frequency of many common malignancies despite long-term immunosuppression.
机译：与普通人群相比，心脏移植接受者中淋巴瘤和皮肤癌的发病率有所增加。然而，尚未将心脏移植接受者从头实体瘤的发生率与一般人群进行比较。因此，从1994年1月1日至2007年5月31日，在一个大型中心对851名连续的成人心脏移植受者进行了随访，以确定从头实体瘤恶性肿瘤的发生率和类型。将观察到的每种癌症类型的发生率与“监视流行病学最终结果”数据库中的预期发生率进行比较，以匹配年龄，性别和种族。观察计数除以预期计数可得出标准化的发生率（SIR），并对其重要性进行了测试。在851例患者中，有73例（8.6％）发生了从头实体瘤恶性肿瘤。在移植时年龄为58 +/- 8岁的60名男性（83.3％）和12名女性（16.7％）被诊断为62 +/- 8岁。癌症分为22类，最常见的3种癌症是前列腺癌（22），肺癌（8）和乳腺癌（6）。子宫颈癌（SIR 14.3，95％置信区间1.7至51.5）和甲状腺癌（SIR 7.7，95％置信区间1.6至22.5）的SIR增加。 Logistic回归表明年龄和移植是癌症的重要危险因素。总之，尽管有长期的免疫抑制作用，但心脏移植患者的许多常见恶性肿瘤发病率并未显着增加。

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