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首页> 外文期刊>The American Journal of Cardiology >Does peak oxygen pulse complement peak oxygen uptake in risk stratifying patients with heart failure?
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Does peak oxygen pulse complement peak oxygen uptake in risk stratifying patients with heart failure?

机译：在将心力衰竭患者分层的风险中，峰值氧气脉冲是否可以补充峰值氧气摄入量？

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There is scarce information regarding the prognostic utility of peak exercise oxygen pulse (peak O(2) pulse), a surrogate for stroke volume, in patients with heart failure (HF). From May 1994 to November 2007, 998 patients with HF underwent cardiopulmonary exercise testing. The ability of peak oxygen uptake (VO(2)) and peak O(2) pulse to predict cardiac events was examined. Peak O(2) pulse was calculated by dividing peak VO(2) by heart rate at the time peak VO(2) was achieved and was expressed in both milliliters per beat and as a percentage achieved of the age-predicted value. There were 212 cardiac events (176 deaths, 26 transplantations, and 10 left ventricular assist device implantations) over a mean of 28 +/- 26 months of follow-up. Peak VO(2) and age-predicted peak O(2) pulse were demonstrated by univariate and multivariate Cox regression analyses to be independent predictors of mortality (p <0.001). The optimal cut points for peak VO(2) and age-predicted peak O(2) pulse (<14.3 and > or =14.3 [mL/kg(-1)/min(-1)] and <85% and > or =85%, respectively) were established by areas under the receiver-operating characteristic curves. Patients exhibiting abnormalities for both responses had 4.8-fold (95% confidence interval 2.7 to 8.5) and 6.7-fold (95% confidence interval 4.1 to 11.1) higher risks for mortality and cardiac events, respectively, than those whose responses were normal. Age-predicted peak O(2) pulse also predicted mortality in patients in the intermediate range of peak VO(2) (10 to 14 (mL/kg(-1)/min(-1))). The 3-year mortality rate for patients in this range who had age-predicted peak O(2) pulse values <85% was even slightly higher than those with peak VO(2) <10.1 (mL/kg(-1)/min(-1)). In conclusion, age-predicted peak O(2) pulse was a strong and independent predictor of cardiac mortality and complemented peak VO(2) in predicting risk in patients with HF.
机译：关于心力衰竭（HF）患者中峰值运动氧脉冲（峰值O（2）脉冲）（作为中风量的替代指标）的预后效用的信息很少。 1994年5月至2007年11月，对998例HF患者进行了心肺运动测试。检查了峰值摄氧量（VO（2））和峰值O（2）脉冲预测心脏事件的能力。通过在达到峰值VO（2）时将峰值VO（2）除以心率来计算峰值O（2）脉冲，并以每搏毫升数和达到的年龄预测值的百分比表示。平均随访28 +/- 26个月，发生了212例心脏事件（176例死亡，26例移植和10例左心室辅助装置植入）。单变量和多变量Cox回归分析证明了峰值VO（2）和年龄预测的峰值O（2）脉冲是死亡率的独立预测因子（p <0.001）。峰值VO（2）和年龄预测的峰值O（2）脉冲的最佳切点（<14.3和>或= 14.3 [mL / kg（-1）/ min（-1）]和<85％和>或分别由接收器工作特性曲线下的面积确定（= 85％）。对两种反应均表现出异常的患者，其死亡率和心脏事件的危险性分别比正常反应者高4.8倍（95％置信区间2.7至8.5）和6.7倍（95％置信区间4.1至11.1）。年龄预测的峰值O（2）脉冲还预测了峰值VO（2）（10至14（mL / kg（-1）/ min（-1））的中间范围内的患者死亡率。在该范围内，年龄预测的O（2）脉搏峰值<85％的患者的三年死亡率甚至比VO（2）峰值<10.1（mL / kg（-1）/ min）的患者更高。 （-1））。总之，年龄预测的峰值O（2）脉冲是心脏死亡的有力且独立的预测因子，在预测HF患者的风险时是峰值VO（2）的补充。

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