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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Evaluation of guinea pig model for ocular and cervical vestibular-evoked myogenic potentials for vestibular function test.
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Evaluation of guinea pig model for ocular and cervical vestibular-evoked myogenic potentials for vestibular function test.

机译：豚鼠模型对眼和颈前庭诱发的肌源性潜力进行前庭功能测试的评估。

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OBJECTIVES/HYPOTHESIS: This study used air-conducted sound (ACS) and bone-conducted vibration (BCV) stimuli in eliciting ocular vestibular-evoked myogenic potential (oVEMP) and cervical VEMP (cVEMP) in guinea pigs. STUDY DESIGN: Prospective study. METHODS: Ten guinea pigs were treated with gentamicin (4 mg) on the left ear, whereas the right ear served as a control. One week after treatment, each animal underwent oVEMP and cVEMP tests using ACS and BCV modes in a randomized order, and was sacrificed for morphological study. RESULTS: Using ACS mode, oVEMPs were absent in all 10 (100%) animals despite the stimulus intensity increased up to 120 dB pe SPL. Conversely, using BCV mode, oVEMPs were present on the left (lesion) eye, and absent on the right (control) eye in all (100%) animals. For the cVEMPs via ACS mode, all right (control) necks had clear cVEMPs, and all (100%) left (lesion) necks revealed absent cVEMPs. However, via BCV mode, all right (control) necks and six (60%) left (lesion) necks showed clear cVEMPs. Morphological study demonstrated substantial loss of hair cells in the utricular and saccular macula. CONCLUSIONS: The cVEMP test via ACS mode is specific for investigating the saccular disorder, whereas the oVEMP test via BCV mode is preferable for investigating the utricular disorders in humans. The guinea pig model is consistent with the findings of humans. Restated, appropriate animal models for cVEMP and oVEMP in guinea pigs are via ACS and BCV modes, respectively.
机译：目的/假设：这项研究使用了空气传导声（ACS）和骨传导振动（BCV）刺激来诱发豚鼠眼前庭诱发的肌源性电位（oVEMP）和宫颈VEMP（cVEMP）。研究设计：前瞻性研究。方法：十只豚鼠在左耳接受庆大霉素（4 mg）治疗，而右耳作为对照组。治疗后一周，每只动物以ACS和BCV模式随机接受oVEMP和cVEMP测试，并处死以进行形态学研究。结果：使用ACS模式，尽管刺激强度增加到120 dB pe SPL，但所有10只（100％）动物均不存在oVEMP。相反，在所有（100％）动物中，使用BCV模式时，oVEMPs出现在左（病变）眼上，而右（对照）眼则不存在。对于通过ACS模式的cVEMP，所有右（对照）颈部均具有清晰的cVEMP，而所有（100％）左（病变）颈部均显示缺少cVEMP。但是，通过BCV模式，所有右（对照）脖子和六个（60％）左（病变）脖子显示出清晰的cVEMP。形态学研究表明，在黄斑部和囊状黄斑中毛细胞大量损失。结论：通过ACS模式的cVEMP测试专门用于研究囊性疾病，而通过BCV模式的oVEMP测试对于研究人类的尿道疾病更为可取。豚鼠模型与人类的发现是一致的。分别通过ACS和BCV模式对豚鼠中的cVEMP和oVEMP进行了重述，适当的动物模型。

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