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首页> 外文期刊>The American Journal of Cardiology >Outcomes in patients with unprotected left main coronary disease: Comparison between drug-eluting stents and coronary artery by-pass grafting
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Outcomes in patients with unprotected left main coronary disease: Comparison between drug-eluting stents and coronary artery by-pass grafting

机译：无保护的左主干冠状动脉疾病患者的治疗结果：药物洗脱支架与冠状动脉旁路移植术的比较

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摘要

In comparing outcomes between drug-eluting stents (DES) and coronary artery bypass grafting for unprotected left main coronary disease, the meta-analysis by Jiang et al included 16 studies in which major adverse cardiac and cerebrovascular events (MACCEs) were assessed with a follow-up period of <=2 years. We reexamined the same 16 studies (and their results on the basis of this follow-up length) to determine whether any temporal trend could be detected in the risk ratio (RR) for 3 main outcome measures (MACCEs including target vessel revascularization [TVR], MACCEs excluding TVR, and TVR). Temporal trends were investigated using standard meta-regression methods; as usual, RR values were log transformed. We reextracted the event frequencies from the primary studies because Jiang et al1 did not present crude event rates. Two of us (A.M. and D.M.) separately carried out this extraction; differences were resolved by consensus, but priority was assigned to outcomes determined after a follow-up period of about 2 years. In analyzing temporal trends, individual studies were represented by the midpoint of their enrollment interval.
机译：在比较药物洗脱支架（DES）和冠状动脉搭桥术治疗未保护的左主冠状动脉疾病之间的结果时，Jiang等人的荟萃分析包括16项研究，其中评估了主要的不良心脏和脑血管事件（MACCE） <= 2年的更新期。我们重新审查了相同的16项研究（及其在此随访时间的基础上得出的结果），以确定是否可以在3种主要结局指标（包括目标血管血运重建[TVR]的MACCE）的风险比（RR）中检测到任何时间趋势，MACCE（不包括TVR和TVR）。使用标准的元回归方法研究了时间趋势。像往常一样，将RR值进行对数转换。我们从主要研究中重新提取了事件发生的频率，因为Jiang等[1]并未给出粗略的事件发生率。我们两个人（上午和下午）分别进行了提取;差异可以通过共识解决，但优先考虑的是在约2年的随访期后确定的结局。在分析时间趋势时，个别研究以其入学间隔的中点表示。

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