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首页> 外文期刊>The American Journal of Cardiology >Gender comparisons in cardiogenic shock during st elevation myocardial infarction treated by primary percutaneous coronary intervention
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Gender comparisons in cardiogenic shock during st elevation myocardial infarction treated by primary percutaneous coronary intervention

机译：原发性经皮冠状动脉介入治疗在st抬高型心肌梗死期间心源性休克的性别比较

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Among patients hospitalized with acute myocardial infarction (AMI), cardiogenic shock (CS) is the leading cause of death, complicating up to 10% of admissions. Introduction of early revascularization strategies and mechanical ventricular support have seen short-term mortality associated with CS fall from 70% to 80% in the 1970s to approximately 50% to 60% in the 1990s. Previous studies reported a higher incidence of CS after AMI in women (11.6% vs 8.3%). The aims of this study were to determine hospital mortality outcomes and gender differences following primary percutaneous coronary intervention (PPCI) in the setting of CS. Data were collected prospectively among all patients undergoing PPCI for AMI at a large UK tertiary cardiac center between April 2008 and October 2011. A sample of 2,864 patients (women: 844 [29.5%]) underwent PPCI, of which 141 (4.9%) had a confirmed diagnosis of CS. Eighty-one of 2,019 [4.0%] male patients (mean age: 64.2 years) and 60 of 844 [7.1%]) female patients (mean age: 69.9 years) with CS underwent PPCI (p <0.001). The overall hospital mortality was 35.5% with no gender difference (male: 35.8% vs female: 35%, p >0.99). In conclusion, this analysis demonstrates that in the contemporary PPCI era, there is a reduction in the incidence of CS with reduced hospital mortality rates and no gender difference. The absence of a gender difference is remarkable because higher proportions of women presented with CS and were older than their male counterparts. Long-term follow-up data are required to determine if this difference is sustained.
机译：在住院的急性心肌梗塞（AMI）患者中，心源性休克（CS）是主要的死亡原因，使入院率最高复杂化了10％。引入早期血运重建策略和机械性心室支持已发现，与CS相关的短期死亡率从1970年代的70％降至80％降至1990年代的约50％至60％。先前的研究报道女性AMI后CS的发生率更高（11.6％对8.3％）。这项研究的目的是确定在CS情况下，原发性经皮冠状动脉介入治疗（PPCI）后的医院死亡率结果和性别差异。在2008年4月至2011年10月之间，对英国一家大型三级心脏中心接受AMI的PPCI的所有患者进行前瞻性收集数据。对2,864例患者（女性：844 [29.5％]）进行了PPCI样本，其中141例（4.9％）接受了PPCI。确诊为CS。患有CS的2 019名男性患者（平均年龄：64.2岁）中的八十一名（平均年龄：64.2岁）和844名女性患者（平均年龄：69.9岁）中的60名（平均年龄：69.9岁）接受了PPCI（p <0.001）。医院总死亡率为35.5％，无性别差异（男性：35.8％，女性：35％，p> 0.99）。总之，该分析表明，在当代的PPCI时代，CS的发生率降低了，医院的死亡率也降低了，并且没有性别差异。没有性别差异是很明显的，因为出现CS的女性比例更高，并且年龄要大于男性。需要长期的随访数据来确定这种差异是否持续。

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