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首页> 外文期刊>The American Journal of Cardiology >Evaluation of framingham and systematic coronary risk evaluation scores by coronary computed tomographic angiography in asymptomatic adults
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Evaluation of framingham and systematic coronary risk evaluation scores by coronary computed tomographic angiography in asymptomatic adults

机译：无症状成人通过冠状动脉计算机断层血管造影术评估弗雷明汉和系统性冠心病危险评分

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Recently, coronary computed tomographic angiography (CCTA) was introduced as a tool for the early detection of coronary atherosclerosis. However, a disagreement exists regarding the accuracy of CCTA for the prediction of future cardiovascular risk compared to conventional clinical risks scores (e.g., Framingham and Systematic Coronary Risk Evaluation [SCORE] scores). The aim of the present study was to compare these 2 methods in asymptomatic Israeli subjects. CCTA was performed in 190 asymptomatic patients with ??1 atherogenic risk factor as the primary screening tool for the presence of cardiovascular disease. The calcium score (CS) was measured in these subjects as a part of CCTA. In addition, the Framingham and SCORE scores were calculated, and statistical analysis using regression models was performed. The study included 190 subjects (84% men). The mean age was 55 ?? 9.7 years. A significant correlation with the CS and plaque severity detected by CCTA was found when comparing the risk factors calculated by the SCORE and Framingham scores. A SCORE calculation of >2 versus <2 was related to a greater incidence of a CS >100 (42.9% vs 21.9; odds ratio [OR] 2.68, p = 0.001). When comparing high-risk (>4) and low-risk (<4) SCORE scores, the risk of atherosclerosis per CCTA was 50% versus 27.1% respectively (OR 2.7, p = 0.001). A high-risk Framingham (>20) versus low-risk Framingham (<20) score was related to a greater incidence of CS >100 (53.3% vs 28.6%; OR 3.18, p = 0.001). A high-risk versus low-risk SCORE score was related to greater plaque severity (79.2% vs 59.4%, respectively; OR 2.6, p = 0.001). A high-risk versus low-risk Framingham score was also related to greater plaque severity (93.3% vs 59%, respectively; OR 3.18, p = 0.001). The variables best predicting the severity of artery stenosis were age, gender, diabetes, and hypertension. In conclusion, the results of the present study indicate that the results of the Framingham and SCORE scores compared to those obtained using CCTA are good predictors of coronary artery disease. The use of these clinical scores seems important in identifying patients at risk of coronary atherosclerosis and treating them properly before the development of symptoms and also to help prevent the use of unnecessary invasive procedures. ? 2013 Elsevier Inc. All rights reserved.
机译：最近，冠状动脉计算机断层血管造影术（CCTA）被引入作为早期检测冠状动脉粥样硬化的工具。但是，与常规临床风险评分（例如Framingham和系统性冠状动脉风险评估[SCORE]评分）相比，CCTA在预测未来心血管风险的准确性方面存在分歧。本研究的目的是在无症状的以色列受试者中比较这两种方法。 CCTA是在190名无动脉粥样硬化风险因子的无症状患者中进行的，作为心血管疾病存在的主要筛查工具。作为CCTA的一部分，对这些受试者的钙分（CS）进行了测量。此外，计算Framingham和SCORE得分，并使用回归模型进行统计分析。该研究包括190名受试者（男性占84％）。平均年龄为55 ?? 9.7年当比较由SCORE和Framingham分数计算出的危险因素时，发现与CCTA检测到的CS和斑块严重程度存在显着相关性。 > 2 vs <2的SCORE计算与CS> 100的发生率更高有关（42.9％vs 21.9;优势比[OR] 2.68，p = 0.001）。比较高风险（> 4）和低风险（<4）SCORE分数时，每个CCTA的动脉粥样硬化风险分别为50％和27.1％（或2.7，p = 0.001）。高风险弗雷明汉（> 20）与低风险弗雷明汉（<20）得分与CS> 100的发生率更高有关（53.3％对28.6％; OR 3.18，p = 0.001）。高风险与低风险的SCORE评分与斑块严重程度更高有关（分别为79.2％和59.4％; OR 2.6，p = 0.001）。高风险与低风险的弗雷明汉评分也与斑块严重程度更高有关（分别为93.3％和59％; OR 3.18，p = 0.001）。最能预测动脉狭窄程度的变量是年龄，性别，糖尿病和高血压。总之，本研究的结果表明，与使用CCTA获得的结果相比，Framingham和SCORE得分的结果是冠心病的良好预测指标。这些临床评分的使用对于识别有冠状动脉粥样硬化风险的患者并在症状发展之前对其进行适当治疗以及帮助防止使用不必要的侵入性程序而言似乎很重要。 ？ 2013 Elsevier Inc.保留所有权利。

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