...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Outcomes of drug-eluting stents for protected left main coronary artery disease (from the multicenter, United States DEScover registry)
【24h】

Outcomes of drug-eluting stents for protected left main coronary artery disease (from the multicenter, United States DEScover registry)

机译：药物洗脱支架治疗左主干冠状动脉疾病的结果（来自美国DEScover注册中心的多中心）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Percutaneous coronary intervention (PCI) for protected left main coronary artery (PLM) disease is complex because of patient and lesion factors; however, limited data exist on the outcomes of drug-eluting stent (DES) use for this indication. DEScover is a prospective observational study that enrolled consecutive patients with PCI in 2005. In-hospital and 1-year statuses were analyzed for 6,172 patients treated with DES according to LM and coronary artery bypass grafting (CABG) statuses (PLM, n = 93; previous CABG native vessel non-LM, n = 722; no previous CABG, n = 5,357). Cumulative event rates were calculated by the KaplanMeier method. Cox proportional hazards regression was used for multivariable analysis of adverse events. Baseline clinical, angiographic, and procedural variables differed significantly among groups, with patients with previous CABG, PLM, and non-LM having higher risk characteristics. In patients with previous CABG, after adjustment with CABG non-LM as a reference group, there were no significant differences in 1-year risk of any adverse event except a trend toward a greater risk of myocardial infarction (MI) in patients with PLM (adjusted hazard ratio 2.4, confidence interval 0.95 to 6.2, p = 0.06). However, patients after CABG (PLM and non-LM) compared to patients without previous CABG had a similar adjusted risk of death, MI, and stent thrombosis; an increased risk of target lesion revascularization (adjusted hazard ratio 1.79, confidence interval 1.2 to 2.6, p = 0.003), target vessel revascularization and death/MI/target vessel revascularization; and a lower risk of CABG (adjusted hazard ratio 0.25, confidence interval 0.09 to 0.67, p = 0.006). In conclusion, status after CABG rather than PLM location increases the risk of repeat revascularization with PCI in DES-treated patients.
机译：由于患者和病变因素，经皮冠状动脉介入治疗（PCI）对受保护的左主冠状动脉（PLM）疾病很复杂。然而，关于药物洗脱支架（DES）用于该适应症的疗效数据有限。 DEScover是一项前瞻性观察性研究，于2005年纳入了连续的PCI患者。根据LM和冠状动脉搭桥术（CABG）的状态，分析了6172名接受DES治疗的患者的住院和1年状态（PLM，n = 93; n = 93; n = 9。先前的CABG本地血管非LM，n = 722;没有先前的CABG，n = 5,357）。累积事件发生率通过KaplanMeier方法计算。 Cox比例风险回归用于不良事件的多变量分析。基线临床，血管造影和手术变量在各组之间存在显着差异，既往患有CABG，PLM和非LM的患者具有较高的风险特征。对于既往有CABG的患者，以CABG非LM为参考组进行调整后，除了PLM患者的心肌梗死（MI）风险增加趋势外，任何不良事件的1年风险无显着差异（调整后的危险比2.4，置信区间0.95至6.2，p = 0.06）。然而，与未接受CABG的患者相比，接受CABG的患者（PLM和非LM）的死亡，心梗和支架血栓形成的调整后风险相似。目标病变血运重建的风险增加（风险比调整为1.79，置信区间1.2至2.6，p = 0.003），目标血管血运重建和死亡/ MI /目标血管血运重建;降低CABG的风险（调整后的危险比0.25，置信区间0.09至0.67，p = 0.006）。总之，在DES治疗的患者中，CABG后的状态而不是PLM的位置增加了PCI再次血运重建的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号