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首页> 外文期刊>The American Journal of Cardiology >Comparison of Angiographic Burden of Coronary Artery Disease in Patients With Versus Without Hepatitis C Infection
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Comparison of Angiographic Burden of Coronary Artery Disease in Patients With Versus Without Hepatitis C Infection

机译：没有丙型肝炎感染的患者冠状动脉疾病血管造影负担的比较

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Hepatitis C virus (HCV) infection is thought to be associated with an increased risk of coronary heart disease (CHD) events, perhaps secondary to increased inflammation. We sought to examine the angiographic burden of coronary artery disease (CAD) in patients with HCV compared to HCV-negative patients. All consecutive HCV RNA positive patients (n = 61) who underwent coronary angiography at the University of Arkansas for Medical Sciences from 2001 to 2013 were identified. A parallel group of HCV-negative controls (n = 61), matched for age, gender, and indication for coronary angiography served as control. Angiographic burden of CAD was assessed by computing Gensini scores. Statistical analysis was performed using SPSS 21.0. Patients with HCV had significantly lower levels of total and low-density lipoprotein cholesterol. Preangiographic use of aspirin and statin was significantly lower in the HCV cohort. Number of patients with obstructive CAD was less in HCV group (23% vs 39%, p <0.05). However, angiographic Gensini score was similar in both groups. There was no correlation between HCV RNA titers and Gensini score (p = 0.9, analysis of variance). In conclusion, patients with active HCV infection have similar angiographic CAD burden as HCV-negative patients. Furthermore, viral load does not appear to correlate with atherosclerosis burden. Patients with HCV have less-obstructive CAD and less-frequent use of aspirin and statins. (C) 2015 Elsevier Inc. All rights reserved.
机译：丙型肝炎病毒（HCV）感染被认为与冠心病（CHD）事件的风险增加有关，也许是继发于炎症增加之后的结果。我们试图检查与HCV阴性患者相比HCV患者的冠状动脉疾病（CAD）的血管造影负担。确定了从2001年至2013年在阿肯色大学医学院接受冠状动脉造影术的所有连续HCV RNA阳性患者（n = 61）。对照组，年龄，性别和冠状动脉造影指征匹配的HCV阴性对照组（n = 61）作为对照组。通过计算Gensini评分评估CAD的血管造影负担。使用SPSS 21.0进行统计分析。 HCV患者的总脂蛋白胆固醇和低密度脂蛋白胆固醇水平明显降低。在HCV队列中，阿斯匹林和他汀类药物在血管造影前的使用显着降低。 HCV组阻塞性CAD患者人数较少（23％vs 39％，p <0.05）。但是，两组的血管造影Gensini评分相似。 HCV RNA滴度与Gensini评分之间无相关性（p = 0.9，方差分析）。总之，活动性HCV感染患者的血管造影CAD负担与HCV阴性患者相似。此外，病毒载量似乎与动脉粥样硬化负担不相关。 HCV患者的CAD梗阻较小，阿司匹林和他汀类药物的使用频率较低。 （C）2015 Elsevier Inc.保留所有权利。

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