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首页> 外文期刊>The American Journal of Cardiology >Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting
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Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting

机译：姜黄素对冠状动脉搭桥术后急性心肌梗死发生率的影响

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It is well established that myocardial infarction (MI) associated with coronary artery bypass grafting (CABG) predicts a poor outcome. Nevertheless, cardioprotective therapies to limit myocardial injury after CABG are lacking. Previous studies have shown that curcuminoids decrease proinflammatory cytokines during cardiopulmonary bypass surgery and decrease the occurrence of cardiomyocytic apoptosis after cardiac ischemia/reperfusion injury in animal models. We aimed to evaluate whether curcuminoids prevent MI after CABG compared to placebo. The 121 consecutive patients undergoing CABG were randomly allocated to receive placebo or curcuminoids 4 g/day beginning 3 days before the scheduled surgery and continued until 5 days after surgery. The primary end point was incidence of in-hospital MI. The secondary end point was the effect of curcuminoids on C-reactive protein, plasma malondialdehyde, and N-terminal pro-B-type natriuretic peptide levels. Baseline characteristics were comparable between the curcuminoid and placebo groups. Mean age was 61 ± 9 years. On-pump CABG procedures were performed in 51.2% of patients. Incidence of in-hospital MI was decreased from 30.0% in the placebo group to 13.1% in the curcuminoid group (adjusted hazard ratio 0.35, 0.13 to 0.95, p = 0.038). Postoperative C-reactive protein, malondialdehyde, and N-terminal pro-B-type natriuretic peptide levels were also lower in the curcuminoid than in the placebo group. In conclusion, we demonstrated that curcuminoids significantly decreased MI associated with CABG. The antioxidant and anti-inflammatory effects of curcuminoids may account for their cardioprotective effects shown in this study.
机译：众所周知，与冠状动脉搭桥术（CABG）相关的心肌梗塞（MI）会预示不良结果。然而，缺乏CABG后限制心肌损伤的心脏保护疗法。先前的研究表明，在动物模型中，姜黄素可减少体外循环手术中的促炎细胞因子，并减少心脏缺血/再灌注损伤后心肌细胞凋亡的发生。我们的目的是评估与安慰剂相比，姜黄素是否能预防CABG后发生心梗。 121名连续接受CABG的患者被随机分配到计划手术前3天开始，每天4 g /天接受安慰剂或姜黄素，并持续到手术后5天。主要终点是院内MI的发生率。次要终点是姜黄素对C反应蛋白，血浆丙二醛和N端促B型利尿钠肽水平的影响。姜黄素组和安慰剂组的基线特征相当。平均年龄为61±9岁。在51.2％的患者中进行了泵上CABG手术。院内MI的发生率从安慰剂组的30.0％降低至姜黄素组的13.1％（调整后的危险比0.35，0.13至0.95，p = 0.038）。姜黄素中的术后C反应蛋白，丙二醛和N端前B型利钠肽水平也低于安慰剂组。总之，我们证明了姜黄素能显着降低与CABG相关的MI。姜黄素的抗氧化和抗炎作用可能是其这项研究中显示的心脏保护作用的原因。

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