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首页> 外文期刊>The American Journal of Cardiology >Effect of interventional stent treatment of native and recurrent coarctation of aorta on blood pressure
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Effect of interventional stent treatment of native and recurrent coarctation of aorta on blood pressure

机译：介入支架治疗主动脉缩窄和缩窄对血压的影响

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The aim of this study was to describe the clinical impact of management of coarctation of the aorta by transcatheter stent placement in the context of longer term management of systemic hypertension. In the long term, poor outlook associated with untreated coarctation of the aorta is likely to relate to uncontrolled systemic hypertension. Transcatheter stent placement to treat native and recurrent coarctation of the aorta is an established therapy in adolescents and adults. There remains confusion about longer term outcomes, particularly the relation between procedural success and improvement in blood pressure (BP) control. Improvement in lifelong systemic BP control after transcatheter stent placement remains unproved. Forty patients underwent transcatheter stent placement over a 10-year period (2001 to 2010) at the Yorkshire Heart Centre. The average age at the time of procedure was 25 years (range 14 to 57). There was a reduction in peak systolic gradient across the coarcted segment from 25 to <10 mm Hg in 35 of 39 patients. After stent placement, there was a significant improvement in systolic BP control at early and later follow-up (mean 155 mm Hg before the procedure and 134 mm Hg at 2.81-year follow-up, p <0.0001). There was 1 early procedural adverse event (stent embolization) and 1 late adverse event (lower limb claudication). In conclusion, transcatheter stent placement for the management of aortic coarctation is associated with a reduction in systolic BP that is maintained over the medium term. A significant minority of patients remain significantly hypertensive, and the best management strategy for this group of patients remains unclear. ? 2013 Elsevier Inc. All rights reserved.
机译：这项研究的目的是描述在长期管理系统性高血压的情况下，通过经导管支架置入管理主动脉缩窄的临床效果。从长远来看，与主动脉缩窄不加治疗相关的不良前景很可能与无法控制的全身性高血压有关。在青少年和成人中，经导管置入支架以治疗主动脉的固有和复发性缩窄是一种行之有效的疗法。关于长期结果，尤其是程序成功与血压控制改善之间的关系仍然存在困惑。经导管支架置入后终生全身性BP控制的改善仍未得到证实。在约克郡心脏中心的10年期间（2001年至2010年），对40例患者进行了经导管支架置入术。手术时的平均年龄为25岁（14至57岁）。 39名患者中有35名患者的缩窄节段收缩压梯度峰值从25降低至<10 mm Hg。放置支架后，在早期和以后的随访中收缩压控制得到了显着改善（术前平均155 mm Hg，在2.81年的随访中平均134 mm Hg，p <0.0001）。有1例早期手术不良事件（支架栓塞）和1例后期不良事件（下肢c行）。总之，经导管置入用于主动脉缩窄的治疗与在中期维持的收缩压降低有关。少数患者仍显着高血压，对于这一组患者的最佳治疗策略仍不清楚。 ？ 2013 Elsevier Inc.保留所有权利。

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