...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Cardiology >Relation of leptin to left ventricular hypertrophy (from the multi-ethnic study of atherosclerosis)
【24h】

Relation of leptin to left ventricular hypertrophy (from the multi-ethnic study of atherosclerosis)

机译：瘦素与左心室肥大的关系（来自多民族动脉粥样硬化研究）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Increasing adiposity increases the risk for left ventricular (LV) hypertrophy. Adipokines are hormone-like substances from adipose tissue that influence several metabolic pathways relevant to LV hypertrophy. Data were obtained from participants enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent magnetic resonance imaging of the heart and who also had fasting venous blood assayed for 4 distinct adipokines (adiponectin, leptin, tumor necrosis factor-α, and resistin). One-thousand four hundred sixty four MESA participants had complete data. The mean age was 61.5 years, the mean body mass index was 27.6 kg/m2, and 49% were women. With adjustment for age, gender, race, height, and weight, multivariate linear regression modeling revealed that a 1-SD increment in leptin was significantly associated with smaller LV mass (?: -4.66% predicted, p 0.01), LV volume (-5.87% predicted, p 0.01), stroke volume (-3.23 ml, p 0.01), and cardiac output (-120 ml/min, p = 0.01) as well as a lower odds ratio for the presence of LV hypertrophy (odds ratio 0.65, p 0.01), but a higher ejection fraction (0.44%, p = 0.05). Additional adjustment for the traditional cardiovascular disease risk factors, insulin resistance, physical activity, education, income, inflammatory biomarkers, other selected adipokines, and pericardial fat did not materially change the magnitude or significance of the associations. The associations between the other adipokines and LV structure and function were inconsistent and largely nonsignificant. In conclusion, the results indicate that higher levels of leptin are associated with more favorable values of several measures of LV structure and function.
机译：肥胖增加会增加左心室（LV）肥大的风险。脂肪因子是来自脂肪组织的激素样物质，会影响与LV肥大有关的几种代谢途径。数据来自参加动脉粥样硬化多民族研究（MESA）的参与者，他们接受了心脏的磁共振成像，并且他们的空腹静脉血还检测了4种不同的脂联素（脂联素，瘦素，肿瘤坏死因子-α和抵抗素） ）。 144个MESA参与者具有完整的数据。平均年龄为61.5岁，平均体重指数为27.6 kg / m2，女性为49％。通过调整年龄，性别，种族，身高和体重，多元线性回归模型显示瘦素的1-SD升高与较小的左室重量显着相关（？：-4.66％预测值，p <0.01），左室体积（预测为-5.87％，p <0.01），中风量（-3.23 ml，p <0.01）和心输出量（-120 ml / min，p = 0.01），以及存在LV肥大的较低比值比（比值比为0.65，p <0.01），但射血分数更高（0.44％，p = 0.05）。对传统心血管疾病危险因素，胰岛素抵抗，体力活动，教育，收入，炎症生物标志物，其他选定的脂肪因子和心包脂肪的其他调整并未从根本上改变这种关联的程度或意义。其他脂肪因子与左室结构和功能之间的关联是不一致的，并且在很大程度上没有意义。总之，结果表明，瘦素水平越高，LV结构和功能的几种测量值越有利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号