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首页> 外文期刊>The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition >Short-term effects of fish-oil supplementation on heart rate variability in humans: A meta-analysis of randomized controlled trials
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Short-term effects of fish-oil supplementation on heart rate variability in humans: A meta-analysis of randomized controlled trials

机译：补充鱼油对人类心率变异性的短期影响：一项随机对照试验的荟萃分析

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Background: The effects of fish oil on heart rate variability in humans remain unclear. Objective: A meta-analysis of randomized controlled trials was performed to investigate the influence of fish oil on heart rate variability. Design: Human intervention studies were identified by systematic search of PubMed, Embase, The Cochrane Library, and references of related reviews and studies. A random-effects model was applied to estimate the pooled results. Results: Fifteen studies were included. Results of the meta-analysis showed that the SD of normal-to-normal interval [standardized mean difference (SMD) = 0.10, P = 0.35] and square of successive differences (SMD = 0.05, P = 0.35), 2 of the time-domain parameters of heart rate variability, were not significantly influenced by fish-oil supplementation. For the frequency-domain parameters, the high-frequency power (HF), a surrogate of vagal function, was significantly increased by fish-oil supplementation (SMD = 0.30, P = 0.005), the low-frequency power (LF) was not significantly affected (SMD = 0.03, P = 0.79), and the ratio of LF to HF (LF/HF) showed a trend of reduction (SMD = 20.22, P = 0.08). The trend for a treatment effect on LF/HF became significant at P = 0.01 when the 2 studies with a dose <1000 mg/d were omitted. Subgroup analyses according to predefined study characteristics showed no significant results. Conclusion: Short-term fish-oil supplementation may favorably influence the frequency domain of heart rate variability, as indicated by an enhanced vagal tone, which may be an important mechanism underlying the antiarrhythmic and other clinical effects of fish oil.
机译：背景：鱼油对人类心率变异性的影响尚不清楚。目的：进行一项随机对照试验的荟萃分析，以研究鱼油对心率变异性的影响。设计：通过系统搜索PubMed，Embase，Cochrane图书馆以及相关评论和研究的参考文献，确定了人类干预研究。应用随机效应模型估计合并结果。结果：纳入十五项研究。荟萃分析的结果显示，正常至正常间隔的SD [标准平均差（SMD）= 0.10，P = 0.35]和连续差的平方（SMD = 0.05，P = 0.35），是两次的鱼油补充对心率变异性的-域参数没有显着影响。对于频域参数，通过添加鱼油可以显着增加作为迷走神经功能替代物的高频功率（HF）（SMD = 0.30，P = 0.005），而低频功率（LF）则不然。显着影响（SMD = 0.03，P = 0.79），并且LF与HF的比率（LF / HF）呈下降趋势（SMD = 20.22，P = 0.08）。当省略两项剂量<1000 mg / d的研究时，对LF / HF的治疗效果趋势在P = 0.01时变得显着。根据预定义的研究特征进行的亚组分析未显示明显结果。结论：短期补充鱼油可能会对心率变异性的频域产生有利影响，如迷走神经张力增强所表明的那样，这可能是鱼油抗心律失常和其他临床作用的重要机制。

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