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首页> 外文期刊>The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition >Longitudinal examination of 24-h urinary iodine excretion in schoolchildren as a sensitive, hydration status-independent research tool for studying iodine status
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Longitudinal examination of 24-h urinary iodine excretion in schoolchildren as a sensitive, hydration status-independent research tool for studying iodine status

机译：对学龄儿童进行24小时尿碘排泄的纵向检查，作为一种敏感的，与水合作用状况无关的研究工具，用于研究碘的状况

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BACKGROUND: Because worldwide iodine status (IS) depends on continuous fortification, the adequacy of IS needs to be regularly monitored. OBJECTIVE: Our study aimed to evaluate IS in a longitudinal sample of healthy schoolchildren who regularly used table salt iodized with 20 microg I/g. DESIGN: Urine osmolality (Uosm) and 24-h urinary excretion rates of iodine (24-h UI), sodium, creatinine, and total urine volume (24-h Uvol) were measured in 1046 specimens that were collected at repeated intervals from 1996 to 2003 in a sample of 358 German children aged 6-12 y. Energy intake and food consumption were calculated from 3-d weighed dietary records that were collected in parallel to the urine samples. RESULTS: During the 4-y period from 1996 to 1999, the median 24-h UI increased from 87 to 93 microg I/d (P = 0.017), whereas urinary iodine concentration (UIC), Uosm, and 24-h Uvol did not change significantly. Thereafter (from 2000 to 2003), UIC stagnated and Uosm decreased (P = 0.004), whereas 24-h Uvol (P = 0.008) and 24-h UI (P = 0.002) increased. The final median 24-h UI reached 120 microg I/d. Milk, fish, egg, and meat intakes and 24-h sodium excretion were all significant predictors of IS, with an almost doubled contribution from milk intake during the second 4-y period. CONCLUSIONS: Our study shows a continuous improvement of IS in a longitudinal sample of German schoolchildren. This improvement was masked when UIC was used as an IS index, especially from 2000 to 2003 because of changes in hydration status. Thus, in research-oriented studies that focus on UIC measurements, hydration status can be a relevant confounder. Longitudinal analyses of 24-h UI in cohort studies may represent an alternative hydration status-independent tool to examine trends in IS and the contribution of relevant foods to IS.
机译：背景：由于全世界的碘状态（IS）取决于持续的防御工事，因此需要定期监测IS的充分性。目的：我们的研究旨在评估健康学龄儿童的纵向样本中的IS，这些样本经常使用以20微克I / g碘化的食盐。设计：从1996年开始重复测量1046个标本中的尿渗透压（Uosm）和24小时尿排泄率（24小时UI），钠，肌酐和总尿量（24小时Uvol）。到2003年，对358名6-12岁的德国儿童进行了抽样调查。根据与尿液样本平行收集的3天称重饮食记录来计算能量摄入和食物消耗。结果：在1996年至1999年的4年期间，中位24小时UI从87微克I / d增加到93微克（P = 0.017），而尿中碘浓度（UIC），Uosm和24小时Uvol升高了变化不大。此后（2000年至2003年），UIC停滞，Uosm降低（P = 0.004），而24小时Uvol（P = 0.008）和24小时UI（P = 0.002）增加。最终的24小时UI中位数达到120微克I / d。牛奶，鱼，蛋，肉的摄入量和24小时钠排泄都是IS的重要预测指标，在接下来的4年中，牛奶的摄入量几乎增加了一倍。结论：我们的研究表明，在德国学童的纵向样本中，信息系统的持续改进。当UIC用作IS指标时，这种改善被掩盖了，特别是从2000年到2003年，因为水合状态的变化。因此，在专注于UIC测量的以研究为导向的研究中，水合状态可能是一个相关的混杂因素。在队列研究中对24小时UI进行的纵向分析可能代表了一种替代水合作用状态的工具，可以用来检查IS的趋势以及相关食品对IS的贡献。

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