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首页> 外文期刊>The American journal of drug and alcohol abuse >Heavy injection drug use is associated with lower percent body fat in a multi-ethnic cohort of HIV-positive and HIV-negative drug users from three U.S. cities.
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Heavy injection drug use is associated with lower percent body fat in a multi-ethnic cohort of HIV-positive and HIV-negative drug users from three U.S. cities.

机译：在来自美国三个城市的多个HIV阳性和HIV阴性吸毒者群体中，大量使用注射毒品会降低体内脂肪百分比。

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BACKGROUND: The clinical implications of lower body weight in drug using populations are uncertain given that lower mean weights may still fall within the healthy range. OBJECTIVES: To determine the effect of type, mode and frequency of drug use on underlying body composition after accounting for differences in body shape and size. METHODS: We conducted a cross-sectional analysis of 511 participants from the Tufts Nutrition Collaborative (TNC) Study. Data included measures of body composition, a 24-hour dietary recall, and a detailed health history and lifestyle questionnaire. Multivariate regression analysis was used to determine the independent effect of drug use on percent body fat (BF) after adjusting for BMI and waist circumference. RESULTS: Heavy injection drug users (IDUs) had a 2.6% lower percent BF than non-users after adjusting for BMI, waist circumference, and other confounders. (p = 0.0006). Differences in percent BF were predominantly due to higher lean mass, rather than lower fat mass. Cocaine and heroin had similar effects on body composition. CONCLUSIONS: In the U.S., where the general population is prone to over-nutrition, the average percent BF for heavy injectors does not fall into a range low enough to suggest harmful effects. However, in populations with substantial levels of under-nutrition, small differences in percent BF among drug users will have a greater impact on health status. SCIENTIFIC SIGNIFICANCE: Differences in BMI, weight and body composition are not always straightforward. Accounting for underlying nutritional status and relative differences in fat and FFM is critical when interpreting results. diagnosed patients and prevent them from returning to prison.
机译：背景：鉴于较低的平均体重可能仍在健康范围内，因此在使用毒品的人群中降低体重的临床意义尚不确定。目的：在考虑到身体形状和大小的差异后，确定药物使用的类型，方式和频率对基础身体成分的影响。方法：我们对塔夫茨营养合作社（TNC）研究的511名参与者进行了横断面分析。数据包括身体成分的测量，24小时饮食召回以及详细的健康史和生活方式调查表。在调整了BMI和腰围之后，使用多元回归分析来确定药物使用对体重百分比（BF）的独立影响。结果：在调整了BMI，腰围和其他混杂因素之后，重度注射吸毒者（IDU）的BF百分比比未使用者低2.6％。 （p ＝ 0.0006）。高炉百分比的差异主要是由于较高的瘦肉质量而不是较低的脂肪质量。可卡因和海洛因对人体成分的影响相似。结论：在美国，一般人群容易营养过度，重型注射器的平均BF含量不足以表明有害作用。但是，在营养水平严重不足的人群中，吸毒者的BF百分比细微差异将对健康状况产生更大的影响。科学意义：BMI，体重和身体组成的差异并不总是那么直接。在解释结果时，考虑基本的营养状况以及脂肪和FFM的相对差异至关重要。诊断患者并阻止他们返回监狱。

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