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首页> 外文期刊>The American journal of drug and alcohol abuse >Sex differences in non-reinforced responding for cocaine.
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Sex differences in non-reinforced responding for cocaine.

机译：非强化可卡因反应中的性别差异。

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Prior studies report no sex differences in cocaine consumption during maintenance of self-administration. We find female rats show poorer lever discrimination during acquisition of self-administration. Now, we test whether female rats show greater non-reinforced or ineffective responding (presses during infusion and time-out periods as well as inactive lever presses) than male rats during maintenance of cocaine self-administration (.0625-1.0 mg/kg/infusion) in Experiment 1. Persistence of responding during extinction when saline-replaced cocaine was also examined. Whether response differences reflect sex differences in movements under a non-drug condition was tested in Experiment 2. Because cocaine may affect lever press rates differentially between sexes, we examined the effects of cocaine (.3-30 mg/kg; IP) on responding for food in Experiment 3. Cocaine consumption does not differ between female and male rats. However, females respond more during infusion and time-out periods and during extinction than males. There is no sex difference in movements and high cocaine doses decrease responding for food more in female vs. male rats. That females engage in more ineffective responding may represent heightened "craving" and cannot be explained by increased movements or cocaine-stimulated increases in lever pressing. In contrast, responding for cocaine in males appears driven by drug delivery.
机译：先前的研究报告，在维持自我管理期间，可卡因的摄入量没有性别差异。我们发现雌性大鼠在获得自我管理过程中显示出较差的杠杆歧视。现在，我们测试在维持可卡因自我管理期间（0.025-1.0 mg / kg / kg），雌性大鼠是否表现出比雄性大鼠更大的非增强或无效反应（输注和超时期间的压力以及无效的杠杆压力）实验1.灭绝期间的反应持续性，同时还检查了盐水替代的可卡因。在实验2中测试了反应差异是否反映了非药物条件下运动的性别差异。由于可卡因可能会影响性别之间的杠杆按压率差异，因此我们研究了可卡因（.3-30 mg / kg; IP）对反应的影响实验3中食物的可食用性。雌性和雄性大鼠之间的可卡因消耗量没有差异。但是，女性在输液和超时以及灭绝期间的反应比男性要大。在运动上没有性别差异，高剂量的可卡因降低了雌性和雄性大鼠对食物的反应。女性参与更无效的回应可能表示“渴望”增加，不能用动作增加或可卡因刺激的杠杆增加来解释。相比之下，男性对可卡因的反应似乎是由药物递送驱动的。

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