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首页> 外文期刊>The Journal of Experimental Biology >Lipid compositional correlates of temperature-adaptive interspecific differences in membrane physical structure
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Lipid compositional correlates of temperature-adaptive interspecific differences in membrane physical structure

机译：膜物理结构中温度适应种间差异的脂质组成相关性

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Teleost species from cold environments possess more disordered brain synaptic membranes than species from warm habitats, thereby providing equivalent physical structures at their respective habitat temperatures. We have related this adaptive interspecific biophysical response to the fatty acid composition of brain membranes from 17 teleost species obtained from Antarctic, temperate and semi-tropical waters, as well as from rat and turkey as representative homeotherms. Cold-adaptive increases in membrane disorder (determined by fluorescence anisotropy with diphenylhexatriene as probe) were correlated with large and linear increases in the proportion of unsaturated fatty acids, from 35 to 60% in phosphatidylcholine (PtdCho) and from 55 to 85% in phosphatidylethanolamine (PtdEth), For PtdCho, the cold-adaptive increase in unsaturation was associated almost entirely with increased proportions (from 7 to 40%) of polyunsaturated fatty acids (PUFAs), with monounsaturates (MUFAs) providing an approximately constant proportion in all species. Exactly opposite effects were evident for phosphatidylethanolamine (PtdEth), Thus, the compositional adaptation for PtdCho occurred largely by exchange of polyunsaturated and monounsaturated fatty acid in the sn-2 position, whilst for PtdEth it involved exchanges between saturates and monounsaturates at the sn-l position. This difference may be related to the different molecular shapes of the two phosphoglycerides and the need to maintain the balance between bilayer-stabilising and -destabilising tendencies. This comparative study provides a more comprehensive view of the compositional adjustments that accompany and perhaps account for temperature-adaptive interspecific differences in membrane physical structure. [References: 35]
机译：来自寒冷环境的硬骨鱼类物种比来自温暖栖息地的物种具有更多的大脑突触膜，从而在它们各自的栖息地温度下提供相同的物理结构。我们已经将这种适应性种间生物物理反应与从南极，温带和半热带水域以及从大鼠和火鸡中获得的代表代表性的等温线的17种硬骨鱼物种的脑膜脂肪酸组成相关联。膜紊乱的冷适应性增加（由以二苯基己三烯为探针的荧光各向异性确定）与不饱和脂肪酸比例的大幅度线性增加相关，磷脂酰胆碱（PtdCho）从35％增加到60％，磷脂酰乙醇胺从55％增加到85％ （PtdEth），对于PtdCho，冷不饱和度的增加几乎完全与多不饱和脂肪酸（PUFA）的比例增加（从7％到40％）有关，而单不饱和脂肪酸（MUFA）在所有物种中的比例大致恒定。磷脂酰乙醇胺（PtdEth）的作用完全相反，因此，对PtdCho的成分适应主要是通过在sn-2位上交换多不饱和和单不饱和脂肪酸而发生的，而对于PtdEth，它涉及在sn-1处饱和和单不饱和之间的交换。位置。这种差异可能与两种磷酸甘油酯的分子形状不同以及需要保持双层稳定和不稳定趋势之间的平衡有关。这项比较研究提供了对膜物理结构中伴随温度调节的种间差异的可能成分调整的更全面的了解。 [参考：35]

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