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首页> 外文期刊>The Journal of Experimental Biology >GABA and responses to GABA in the stomatogastric ganglion of the crab Cancer borealis
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GABA and responses to GABA in the stomatogastric ganglion of the crab Cancer borealis

机译：蟹癌胃气门神经节中的GABA及其对GABA的响应

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The multifunctional neural circuits in the crustacean stomatogastric ganglion (STG) are influenced by many small-molecule transmitters and neuropeptides that are co-localized in identified projection neurons to the STG, We describe the pattern of gamma-aminobutyric acid (GABA) immunoreactivity in the stomatogastric nervous system of the crab Cancer borealis and demonstrate biochemically the presence of authentic GABA in C, borealis, No STG somata show GABA immunoreactivity but, within the stomatogastric nervous system, GABA immunoreactivity co-localizes with several neuropeptides in two identified projection neurons, the modulatory proctolin neuron (MPN) and modulatory commissural neuron 1 (MCN1). To determine which actions of these neurons are evoked by GABA it is necessary to determine the physiological actions of GABA on STG neurons. We therefore characterized the response of each type of STG neuron to focally applied GABA, All STC neurons responded to GABA. In some neurons, GABA evoked a picrotoxin-sensitive depolarizing, excitatory response with a reversal potential of approximately -40mV, This response was also activated by muscimol, In many STG neurons, GABA evoked inhibitory responses with both K+-and Cl--dependent components. Muscimol and beta-guanidinopropionic acid weakly activated the inhibitory responses, but many other drugs, including bicuculline and phaclofen, that act on vertebrate GABA receptors were not effective. In summary, GABA is found in projection neurons to the crab STC and can evoke both excitatory and inhibitory actions on STG neurons. [References: 63]
机译：甲壳动物气孔神经节（STG）中的多功能神经回路受许多小分子递质和神经肽的影响，这些递质和神经肽共定位在STG的投射神经元中。我们描述了γ-氨基丁酸（GABA）免疫反应性的模式蟹癌的胃气道神经系统，并从生化方面证明了C的真实GABA的存在，无STG体细胞显示GABA免疫反应，但在胃气道神经系统内，GABA免疫反应与几个已鉴定的投射神经元中的几种神经肽共定位。调节性proctolin神经元（MPN）和调节性连合神经元1（MCN1）。为了确定GABA引起这些神经元的哪些动作，有必要确定GABA对STG神经元的生理作用。因此，我们表征了每种类型的STG神经元对局部应用GABA的反应，所有STC神经元均对GABA作出反应。在一些神经元中，GABA引起对微毒素敏感的去极化兴奋性反应，其逆转电位约为-40mV。这种反应也被麝香酚激活。在许多STG神经元中，GABA引起了K +和Cl依赖成分的抑制性反应。 。麝香酚和β-胍基丙酸微弱地激活了抑制反应，但是作用于脊椎动物GABA受体的许多其他药物，包括比库林和苯氯酚，都无效。总之，在蟹STC的投射神经元中发现了GABA，可以引起对STG神经元的兴奋和抑制作用。 [参考：63]

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