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首页> 外文期刊>The Journal of extra-corporeal technology >An in vitro study of the effectiveness of carbon dioxide flushing of arterial line filters.
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An in vitro study of the effectiveness of carbon dioxide flushing of arterial line filters.

机译：动脉管路过滤器二氧化碳冲洗效果的体外研究。

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Gaseous microemboli (GMEs) have been connected to neurologic impairment and other ischemic complications after surgery. The components of the extracorporeal circuit (ECC) have a large influence on GME production. This in vitro study investigates the use of carbon dioxide flushing of the 38-microm Medtronic Affinity CB351 and 38-microm Medtronic Affinity 351 arterial line filters (ALFs) to decrease GMEs and time for air to clear the ALE An adult circuit was implemented with a silicone oxygenator for vacuum-assisted gas removal and to reduce air before ALE The 48 filters were separated into four equal groups: flushed coated and non-coated and non-flushed coated and non-coated. Carbon dioxide flushing was performed at 6 L/min for 3 minutes. ALFs were retrograde primed at 200 mL/min. An Emboli Detection and Classification Quantifier (EDAC) was used to gather data. The average total emboli and time to clear (seconds) for flush coated were 20.25 +/- 16.78 and 142.17 +/- 174.80 seconds, respectively, flushed non-coated were 30.5 +/- 34.65 and 124.17 +/- 131.40 seconds, non-flushed coated were 162.08 +/- 79.90 and 390.42 +/- 84.36 seconds, and non-flushed non-coated were 163.67 +/- 212.67 and 305.92 +/- 179.36 seconds. Flushed filters had an average total emboli count of 25.375 +/- 27.14 and an average time to clear of 13.167 +/- 151.51 seconds. Non-flushed filters had an average total emboli count of 162.875 +/- 157.11 and an average time to clear of 348.167 +/- 143.70 seconds. Coated and non-coated filters for total emboli and time to clear had p values of .86 and .24, respectively. Flushed and non-flushed filters had total emboli and time to clear p values of < .001 and < .001, respectively. No significant difference was found between coated and non-coated filters involving total embolic count and time to clear. A significant difference was found in total embolic count and time to clear between flushed and non-flushed filters. This study shows that fewer emboli and faster embolic clearance time correlate with carbon dioxide flushing of the ALE.
机译：气态微栓塞（GME）与手术后的神经系统损害和其他缺血性并发症有关。体外电路（ECC）的组件对GME的生产影响很大。这项体外研究调查了使用38微米Medtronic Affinity CB351和38微米Medtronic Affinity 351动脉管路过滤器（ALF）进行二氧化碳冲洗以减少GME和空气清除ALE的时间。硅酮充氧器，用于在ALE之前去除真空辅助气体并减少空气。48个过滤器分为四个相等的组：冲洗涂层和非涂层以及非冲洗涂层和非涂层。以6L / min的速度进行二氧化碳冲洗3分钟。 ALF以200 mL / min的速度逆行灌注。栓子检测和分类量化器（EDAC）用于收集数据。平涂的平均总栓子和清除时间（秒）分别为20.25 +/- 16.78和142.17 +/- 174.80秒，未涂平的分别为30.5 +/- 34.65和124.17 +/- 131.40秒，非冲洗涂层为162.08 +/- 79.90和390.42 +/- 84.36秒，非冲洗非涂层为163.67 +/- 212.67和305.92 +/- 179.36秒。冲洗过的过滤器的平均总栓子数为25.375 +/- 27.14，平均清除时间为13.167 +/- 151.51秒。未冲洗的过滤器的平均总栓子数为162.875 +/- 157.11，平均清除时间为348.167 +/- 143.70秒。涂膜和未涂膜过滤器的总栓塞和清除时间的p值分别为0.86和0.24。冲洗和非冲洗过滤器的总栓塞和清除p值的时间分别为<.001和<.001。涂层和未涂层​​过滤器之间的总栓塞数和清除时间没有发现显着差异。发现在冲洗过的和未冲洗过的过滤器之间，总栓塞数量和清除时间有显着差异。这项研究表明，较少的栓子和更快的栓子清除时间与ALE的二氧化碳冲洗有关。

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