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首页> 外文期刊>The Southeast Asian journal of tropical medicine and public health >PREVALENCE AND GENETIC CHARACTERIZATION OF HUMAN CORONAVIRUSES IN SOUTHERN THAILAND FROM JULY 2009 TO JANUARY 2011
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PREVALENCE AND GENETIC CHARACTERIZATION OF HUMAN CORONAVIRUSES IN SOUTHERN THAILAND FROM JULY 2009 TO JANUARY 2011

机译：2009年7月至2011年1月在泰国南部的人类冠状病毒的流行及其遗传特征

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摘要

Emergence of viruses belonging to the coronavirus family has been widespread in the past, causing respiratory infections in humans, such as severe acute respiratory syndrome (SARS). This study investigated the prevalence of human coronavirus (HCoV) and characterized the molecular viral genetics. We collected 1,254 samples from patients diagnosed with respiratory infection in southern Thailand from July 2009 to January 2011 and screened for HCoV by RT-PCR and genotyped by BLAST analysis of nspl2 gene. Phylogenetic analysis was performed based on S gene sequences. Thirty-five of 1,254 samples were positive for HCoV. Viral genotyping revealed 4 genotypes with HCoV-OC43 being the predominant genotype. Viral prevalence and genotype distribution were not in accordance with seasonal distribution. Phylogenetic analysis and deduced amino acid sequences of the S gene showed amino acid variations in each genotype. The S gene sequence of HCoV-OC43 genotype indicated that it resulted from recombination between subgenotypes B and C. Viral genetics analysis disclosed genetic variations of HCoV and additionally, it can provide information suitable for monitoring and prevention of the emergence and re-emergence of various types of coronavirus.
机译：过去，冠状病毒家族病毒的出现已经很广泛，导致人类呼吸道感染，例如严重的急性呼吸道综合症（SARS）。这项研究调查了人类冠状病毒（HCoV）的流行程度，并表征了分子病毒遗传学。我们从2009年7月至2011年1月在泰国南部诊断为呼吸道感染的患者中收集了1,254个样本，并通过RT-PCR筛选HCoV，并通过nspl2基因的BLAST分析进行基因分型。根据S基因序列进行了系统发育分析。 1,254个样本中有35个为HCoV阳性。病毒基因分型显示出4种基因型，其中HCoV-OC43为主要基因型。病毒感染率和基因型分布与季节分布不一致。系统进化分析和推导的S基因的氨基酸序列显示出每种基因型的氨基酸变异。 HCoV-OC43基因型的S基因序列表明它是由亚型B和C重组引起的。病毒遗传学分析揭示了HCoV的遗传变异，此外，它还可以提供适于监测和预防各种基因的出现和再出现的信息。冠状病毒的类型。

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