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首页> 外文期刊>The Urologic clinics of North America >Cytokine-based therapy for metastatic renal cell cancer.
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Cytokine-based therapy for metastatic renal cell cancer.

机译：基于细胞因子的转移性肾细胞癌治疗。

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摘要

The use of recombinant gene technology to produce commercially available amounts of cytokines heralded an era of clinical applications of immunotherapy. Although the response rates to cytokine therapies are modest and sometimes occur at the expense of great cost and toxicity, they are proof of the principal that even large tumor burdens can be overcome by purely immune modulation. The interleukins and the interferons have been used in various phases of clinical trials in RCC. The maturation and final results of phase III trials are needed to guide clinical practice. In the meantime, the knowledge gained clinically and in the laboratory should lead to continued improvements and outcomes in immunotherapy for RCC.
机译：重组基因技术用于生产可商购量的细胞因子预示着免疫疗法临床应用的时代。尽管对细胞因子疗法的反应率不高，有时会以高昂的成本和毒性为代价，但它们证明了原理，即甚至大的肿瘤负担也可以通过纯粹的免疫调节来克服。白细胞介素和干扰素已用于RCC的临床试验的各个阶段。需要III期试验的成熟度和最终结果来指导临床实践。同时，在临床上和实验室中获得的知识应导致RCC免疫治疗的持续改进和结果。

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