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首页> 外文期刊>The Pediatric infectious disease journal >Antibodies against Haemophilus influenzae type b capsular polysaccharide and tetanus toxoid before and after a booster dose of the carrier protein nine years after primary vaccination with a protein conjugate vaccine.
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Antibodies against Haemophilus influenzae type b capsular polysaccharide and tetanus toxoid before and after a booster dose of the carrier protein nine years after primary vaccination with a protein conjugate vaccine.

机译：在初次接种蛋白质结合疫苗后九年增加剂量的载体蛋白之前和之后，针对b型流感嗜血杆菌荚膜多糖和破伤风类毒素的抗体。

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摘要

IgG antibodies against Haemophilus influenzae type b (Hib) capsular polysaccharide (CPS) and tetanus toxoid (TT) were measured for 53 children, 10 years of age, before and 1 month after a booster dose of diphtheria-tetanus vaccine (DT). All children had been vaccinated at 3, 5 and 12 months of age with DT and a Hib-TT conjugate. Geometric mean concentrations of Hib CPS serum IgG antibody were 4.16 and 4.30 microg/mL before and after the DT booster, respectively. The geometric mean concentration of TT IgG antibody increased from 0.09 IU/mL to 4.58 IU/mL (P < 0.001). Hib CPS IgG levels remained well above protective titers for 9 years after 3 doses of Hib-TT appropriately spaced in infancy. A booster dose of TT did not affect Hib CPS antibody concentrations but induced a pronounced IgG response against TT.
机译：在增加剂量的白喉破伤风疫苗（DT）之前和之后的一个月，对10岁的53名儿童测量了针对b型流感嗜血杆菌（Hib）荚膜多糖（CPS）和破伤风类毒素（TT）的IgG抗体。所有儿童均在3、5和12个月大时接种了DT和Hib-TT偶联物。 DT加强免疫前后，Hib CPS血清IgG抗体的几何平均浓度分别为4.16和4.30 microg / mL。 TT IgG抗体的几何平均浓度从0.09 IU / mL增加到4.58 IU / mL（P <0.001）。在婴儿中适当间隔3剂Hib-TT剂量后的9年中，Hib CPS IgG水平仍远高于保护滴度。 TT的加强剂量不会影响Hib CPS抗体的浓度，但会引起针对TT的明显IgG应答。

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