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首页> 外文期刊>The Pediatric infectious disease journal >Surveillance of Hemolytic Uremic Syndrome in Children Less Than 15 Years of Age, a System to Monitor O157 and Non-O157 Shiga Toxin-Producing Escherichia coli Infections in France, 1996-2006.
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Surveillance of Hemolytic Uremic Syndrome in Children Less Than 15 Years of Age, a System to Monitor O157 and Non-O157 Shiga Toxin-Producing Escherichia coli Infections in France, 1996-2006.

机译:1996年至2006年法国15岁以下儿童溶血性尿毒症综合征的监测,该系统可监测产生O157和非O157志贺毒素的大肠埃希菌感染情况。

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摘要

BACKGROUND:: Since the 1980s, Shiga toxin-producing Escherichia coli (STEC), especially E. coli O157:H7, has been an important cause of food borne disease in industrial countries. In France, as there was no routine screening for STEC in clinical laboratories, enhanced surveillance of hemolytic uremic syndrome (HUS) in children less than 15 years of age was established in 1996 to monitor trends in the incidence of STEC infections. METHODS:: The surveillance system was based on a voluntary national network of pediatricians of 31 pediatric nephrology units in public hospitals. RESULTS:: From 1996 to 2006, the mean annual incidence of HUS was 0.71 cases per 100,000 children less than 15 years of age and 1.87 cases per 100,000 children less than 5 years of age. STEC infections were confirmed in 66% of patients; STEC O157 was the most common serogroup identified in STEC-related HUS (83%). In this 11-year period, 96% of HUS cases were sporadic and only 2 outbreaks caused by STEC O157 and by a dual infection of STEC O26 and O80 were detected. CONCLUSIONS:: An evaluation of the surveillance of pediatric HUS showed that it is a simple and useful system for monitoring trends in STEC infections in France. It provides the information needed to measure the impact of new and changing vehicles of STEC transmission, and evaluate the effectiveness of prevention measures.
机译:背景:自1980年代以来,产生志贺毒素的大肠杆菌(STEC),特别是大肠杆菌O157:H7,已成为工业化国家食源性疾病的重要原因。在法国,由于临床实验室没有常规筛查STEC的方法,因此1996年建立了对15岁以下儿童溶血尿毒症综合征(HUS)的加强监视,以监测STEC感染的发生趋势。方法:监视系统基于公立医院中31个儿科肾脏病科的全国儿科医生自愿网络。结果:从1996年到2006年,HUS的年平均发病率为每10万名15岁以下儿童0.71例,每10万名5岁以下儿童1.87例。在66%的患者中证实了STEC感染; STEC O157是STEC相关HUS中最常见的血清群(83%)。在这11年中,有96%的HUS病例为散发性疾病,仅检测到2例由STEC O157以及STEC O26和O80双重感染引起的暴发。结论:对儿科HUS监测的评估表明,它是一个简单而有用的系统,用于监测法国的STEC感染趋势。它提供了测量STEC变速器的新车和变化车的影响以及评估预防措施的有效性所需的信息。

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