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首页> 外文期刊>The Veterinary Journal >Non-genomic actions of progesterone and estrogens in regulating reproductive events in domestic animals.
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Non-genomic actions of progesterone and estrogens in regulating reproductive events in domestic animals.

机译：孕激素和雌激素在调节家畜繁殖事件中的非基因作用。

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摘要

It has been established that nuclear receptors mediate the action of estrogens and progestins in regulating gene expression in the hypothalamic-hypophyseal-gonadal axis of domestic animals during various reproductive states. Results of recent in vitro studies suggest that estradiol-17beta and progesterone can act non-genomically to affect signal transduction responses in target cells by binding to receptors in the plasma membrane. The genomic action of steroids is generally detectable in hours to days whereas non-genomic responses of cells occur in seconds to minutes. The nature of the plasma membrane receptors for estrogens and progesterone has been explored but has not been conclusively established for all cell types studied. In the ewe, estradiol-17beta or estradiol-bovine serum albumin conjugate has been shown by in vitro and in vivo approaches to act non-genomically to suppress luteinizing hormone secretion by gonadotropes and stimulate production of nitric oxide by uterine arterial endothelial cells. Progesterone has been shown to inhibit oxytocin (OT) binding to its receptor in isolated ovine endometrial plasma membranes. This non-genomic action of progesterone blocks OT activation of the phosphoinositide cascade and production of prostaglandin F(2alpha) by ovine and bovine endometrium. The acrosome reaction of caprine and porcine spermatozoa is activated by the non-genomic action of progesterone. Further research is required to define the biological significances of the non-genomic actions of estrogens and progestins.
机译：已经确定，在各种生殖状态期间，核受体介导雌激素和孕激素调节家畜下丘脑-垂体-性腺轴中基因表达的作用。最近的体外研究结果表明，雌二醇-17β和孕酮可通过与质膜受体结合，以非基因组的方式影响靶细胞的信号转导反应。类固醇的基因组作用通常可在数小时至数天之内检测到，而细胞的非基因组反应则可在数秒至数分钟内发生。已经研究了雌激素和孕酮的质膜受体的性质，但尚未针对所有研究的细胞类型最终确定。在母羊中，已通过体外和体内方法显示雌二醇-17β或雌二醇-牛血清白蛋白结合物可非基因组地抑制促性腺激素促黄体激素分泌并刺激子宫动脉内皮细胞产生一氧化氮。孕酮已显示在分离的绵羊子宫内膜质膜中抑制催产素（OT）与其受体结合。孕酮的这种非基因组作用阻止了OT激活磷酸肌醇级联反应以及绵羊和牛子宫内膜产生前列腺素F（2alpha）。姜黄素和猪精子的顶体反应被孕酮的非基因作用所激活。需要进一步的研究来确定雌激素和孕激素的非基因作用的生物学意义。

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