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首页> 外文期刊>The Veterinary Journal >Congenital sensorineural deafness in dogs: a molecular genetic approach toward unravelling the responsible genes
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Congenital sensorineural deafness in dogs: a molecular genetic approach toward unravelling the responsible genes

机译：狗的先天性感音神经性耳聋：揭露负责任基因的分子遗传学方法

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摘要

Deafness is often diagnosed in different dog breeds and has been identified as a significant problem for breeders, owners and clinicians. The aetiology can be inherited or acquired, and a distinction must be made between sensorineural and conductive forms of deafness. This paper provides a brief overview of the varieties of findings in different dog breeds and in one breed in particular including prevalence, phenotypic and gender associations, histology, modes of inheritance and the number of contributing genes in congenital sensorineural deafness. We have also described molecular genetic approaches to canine hearing loss and discuss how comparative genomics could help reduce the prevalence of deafness in affected breeds leading to new insights into the molecular mechanisms of auditory function in both dogs and humans.
机译：耳聋通常在不同的犬种中被诊断出来，并且已被确定为育种者，主人和临床医生的重要问题。病因可以被继承或获得，必须区分耳聋的感音神经传导和传导神经传导两种形式。本文简要概述了不同犬种（尤其是一个犬种）中发现的种类，包括患病率，表型和性别关联，组织学，遗传方式以及先天性感音神经性耳聋的贡献基因数量。我们还描述了犬类听力丧失的分子遗传方法，并讨论了比较基因组学如何帮助减少受影响品种中耳聋的患病率，从而对狗和人的听觉功能的分子机制产生新见解。

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