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首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study.
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Maternal fat consumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study.

机译：《大阪市母婴健康研究》，孕期孕妇的脂肪消耗以及16-24个月大的日本婴儿的喘息和湿疹风险。

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BACKGROUND: One factor capable of modulating antenatal immune responses is diet. This prospective study examined the association between maternal intake of specific types of fatty acids, cholesterol, fish and meat during pregnancy and the risk of wheeze and eczema in the offspring. METHODS: Subjects were 763 mother-child pairs. Data on maternal intake during pregnancy were assessed with a diet history questionnaire. Data on wheeze and eczema based on criteria of the International Study of Asthma and Allergies in Childhood were obtained from a questionnaire completed by mothers 16-24 months postpartum. RESULTS: Higher maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy was independently associated with a reduced risk of wheeze, but not eczema, in the offspring (adjusted odds ratios (ORs) between extreme quartiles 0.52 (95% CI 0.28 to 0.97) and 0.37 (95% CI 0.15 to 0.91), respectively). Higher maternal intake of n-6 polyunsaturated fatty acids and linoleic acid during pregnancy was independently related to an increased risk of infantile eczema but not wheeze (adjusted ORs 2.25 (95% CI 1.13 to 4.54) and 2.11 (95% CI 1.06 to 4.26), respectively). No significant exposure-response relationships were observed between maternal consumption of total fat, saturated fatty acids, monounsaturated fatty acids, eicosapentaenoic acid, arachidonic acid, cholesterol, meat and fish and the ratio of n-3 to n-6 polyunsaturated fatty acid consumption during pregnancy and infantile wheeze or eczema. CONCLUSIONS: Maternal intake of alpha-linolenic acid and docosahexaenoic acid during pregnancy may be preventive against infantile wheeze. Maternal intake of n-6 polyunsaturated fatty acids, especially linoleic acid, during pregnancy may increase the risk of childhood eczema.
机译：背景：能够调节产前免疫反应的一个因素是饮食。这项前瞻性研究检查了孕妇孕期摄入特定类型的脂肪酸，胆固醇，鱼和肉的类型与后代发生喘息和湿疹的风险之间的关系。方法：受试者为763对母婴。通过饮食史问卷评估了孕期孕产妇摄入量的数据。根据国际儿童哮喘和过敏症研究的标准，从产后16-24个月的母亲填写的问卷中获得有关喘息和湿疹的数据。结果：孕期孕妇较高的α-亚麻酸和二十二碳六烯酸摄入量与降低后代发生喘息的风险相关，但与湿疹风险降低无关（极端四分位数之间的校正比值比（OR）为0.52（95％CI 0.28至0.97） ）和0.37（95％CI分别为0.15至0.91）。孕期孕妇较高的n-6多不饱和脂肪酸和亚油酸摄入量与婴儿湿疹风险增加有关，而与喘息风险无关（OR 2.25（95％CI 1.13至4.54）和2.11（95％CI 1.06至4.26）） ， 分别）。在孕产妇摄入总脂肪，饱和脂肪酸，单不饱和脂肪酸，二十碳五烯酸，花生四烯酸，胆固醇，肉和鱼之间的摄入量与n-3比n-6多不饱和脂肪酸的比例之间没有显着的暴露-反应关系。怀孕和婴儿喘息或湿疹。结论：孕妇在怀孕期间摄入α-亚麻酸和二十二碳六烯酸可以预防婴儿喘鸣。孕妇在怀孕期间摄入n-6多不饱和脂肪酸，尤其是亚油酸可能会增加儿童湿疹的风险。

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